{"id":"W2055346625","doi":"10.1155/2010/613504","title":"Application of “omics” to Prion Biomarker Discovery","year":2010,"lang":"lv","type":"review","venue":"Journal of Biomedicine and Biotechnology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Biomarker discovery; Biomarker; Computational biology; Proteomics; Disease; Omics; Genomics; Biology; Prion protein; Bioinformatics; Medicine; Genome; Gene; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007636403,0.0004024748,0.001350415,0.0008205489,0.00006139804,0.00002351043,0.0005867881,0.001728773,0.000009596855],"category_scores_gemma":[0.0003321723,0.0002931299,0.0004083488,0.0005488336,0.0004756104,0.00001233744,0.0003868794,0.0006210196,0.000004084316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003199804,"about_ca_system_score_gemma":0.0003346961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001763367,"about_ca_topic_score_gemma":0.000004920229,"domain_scores_codex":[0.997532,0.00008248171,0.001387152,0.0004442453,0.0002426826,0.0003115041],"domain_scores_gemma":[0.9971027,0.00004307911,0.001811097,0.0005739016,0.0002384856,0.000230736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001227166,0.00007734077,0.00004089285,0.001030128,0.000172888,0.000008519612,0.000006249125,8.840793e-8,0.3948315,0.00006242852,0.0002911312,0.6033561],"study_design_scores_gemma":[0.0006888573,0.001943332,0.0001113199,0.001774152,0.0006066185,0.0005918745,0.0000580081,0.000009213592,0.04395725,0.00009449109,0.9498738,0.0002910467],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03045239,0.9497674,0.01511468,0.003354726,0.0005535339,0.0006313865,0.0001081872,0.000005669925,0.00001206852],"genre_scores_gemma":[0.04705194,0.9501968,0.001784815,0.0001941477,0.0006030359,0.0000103227,0.00008778495,0.00003429543,0.00003687968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9495827,"threshold_uncertainty_score":0.9999521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088368754711671,"score_gpt":0.2942990799217323,"score_spread":0.2834153923746155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}