{"id":"W2055362351","doi":"10.1042/0264-6021:3530537","title":"Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides","year":2001,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Respiratory viral infections research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital","funders":"Medical Research Council; Medical Research Council Canada; Government of Canada","keywords":"Furin; Proprotein convertase; Cleavage (geology); Glycoprotein; Peptide; Virology; Biology; Virus; Ebola virus; Proprotein Convertases; Biochemistry; Infectivity; Chemistry; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002307688,0.0002914959,0.0001447614,0.0001420441,0.00008651491,0.000240296,0.0001308596,0.0002330892,0.0005582149],"category_scores_gemma":[0.000174563,0.0000955657,0.0003012421,0.0001055781,0.0001750265,0.0001962309,0.00007891716,0.0002133859,0.0001948564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002606465,"about_ca_system_score_gemma":0.0002184588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001821595,"about_ca_topic_score_gemma":0.001547715,"domain_scores_codex":[0.9999014,0.00001742719,0.000008775218,0.00001442686,0.00002787134,0.0000299896],"domain_scores_gemma":[0.9998568,0.00004618229,0.00003002996,0.000009786403,0.00002770936,0.00002951773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001063856,0.000009994118,0.0005822941,0.0000316615,0.00000651795,0.00007534569,0.00001757096,0.00005886683,0.9981114,0.00003572402,0.000005641961,0.000958641],"study_design_scores_gemma":[0.000007375808,0.0003426843,0.01634825,0.000005120302,0.00002784111,0.000334046,0.00004437903,0.0004930712,0.9817509,0.00002193573,0.0006204559,0.000003895695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974084,0.001029148,0.0008881545,0.0000159465,0.000003696771,0.00001281435,0.00009778742,0.000004431697,0.0005395273],"genre_scores_gemma":[0.9953819,0.0008490242,0.001952108,0.00002543163,0.000003589738,0.0000117997,0.0005874085,0.000005183133,0.001183465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821595,"threshold_uncertainty_score":0.003621936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0482886223908013,"score_gpt":0.3468846599078339,"score_spread":0.2985960375170326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}