{"id":"W2055362351","doi":"10.1042/0264-6021:3530537","title":"Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides","year":2001,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Respiratory viral infections research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital","funders":"Medical Research Council; Medical Research Council Canada; Government of Canada","keywords":"Furin; Proprotein convertase; Cleavage (geology); Glycoprotein; Peptide; Virology; Biology; Virus; Ebola virus; Proprotein Convertases; Biochemistry; Infectivity; Chemistry; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006101454,0.000130593,0.0004239787,0.0001757975,0.00007838108,0.00002072737,0.0001688019,0.00008399363,0.00001783934],"category_scores_gemma":[0.0001617459,0.0000690209,0.0001035957,0.0009039037,0.0006363811,0.000087256,0.00006389336,0.0003871096,4.113764e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004699795,"about_ca_system_score_gemma":0.0001769688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002780683,"about_ca_topic_score_gemma":0.00009311926,"domain_scores_codex":[0.9984078,0.0002893597,0.0005080173,0.0001823866,0.000446692,0.0001657037],"domain_scores_gemma":[0.9988704,0.0001221798,0.000338053,0.0003110429,0.0002730969,0.00008520979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008378063,0.0002106384,0.2177194,0.00007097481,0.0002607961,0.00000771918,0.0002837409,0.000007495941,0.7803547,0.00003373235,0.00006629426,0.0001467747],"study_design_scores_gemma":[0.001089109,0.0007448621,0.1764071,0.0001058713,0.0003088441,0.0001356426,0.0005087726,0.00005113858,0.820511,0.00001856254,0.00005551519,0.00006358838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978018,0.001261243,0.00006342798,0.00009826489,0.000004705189,0.0006696999,0.00001342727,0.000003596361,0.0000838413],"genre_scores_gemma":[0.9996704,0.00006320119,0.0001508653,0.00005624186,0.00002814226,0.00001433686,0.000001027853,0.000007180848,0.000008631013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04131231,"threshold_uncertainty_score":0.2814591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0482886223908013,"score_gpt":0.3468846599078339,"score_spread":0.2985960375170326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}