{"id":"W2055389755","doi":"10.1182/blood-2014-05-577825","title":"Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":426,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Dan L. Duncan Cancer Center, Baylor College of Medicine; Lester and Sue Smith Foundation; National Human Genome Research Institute; Texas Children's Hospital; Deutsche Forschungsgemeinschaft; Howard Hughes Medical Institute","keywords":"MAPK/ERK pathway; Somatic cell; Kinase; Mutation; Mutant; Cancer research; Phosphorylation; Biology; Protein kinase A; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580404,0.0001091397,0.000184255,0.0001616653,0.00006346586,0.00001153892,0.00007519246,0.0001246461,0.00008270669],"category_scores_gemma":[0.0001769416,0.0001052537,0.00003986165,0.00007045027,0.00004518548,0.00007327119,0.00003496226,0.0001007496,0.00002324577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001968535,"about_ca_system_score_gemma":0.00005418959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002641051,"about_ca_topic_score_gemma":0.00009800112,"domain_scores_codex":[0.999083,0.0001869492,0.0002551446,0.0001825472,0.0000179641,0.0002744273],"domain_scores_gemma":[0.999552,0.0002344493,0.00006937547,0.0001096707,0.00002083016,0.000013651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004700582,0.0007207816,0.01026854,0.0000577063,0.00006016154,0.000001768165,0.004374718,0.000003994181,0.9667825,0.0008191208,0.00008575875,0.01635487],"study_design_scores_gemma":[0.009468527,0.001154758,0.3842117,0.0001671212,0.00008257933,0.00006505424,0.002216673,0.00009916297,0.5975731,0.00107286,0.003549866,0.0003385753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984519,0.0002870117,0.0002989043,0.0001963959,0.0001358079,0.0003768615,0.00001951596,0.00001809821,0.0002155307],"genre_scores_gemma":[0.9991482,0.00002180962,0.0001671731,0.00009322112,0.00001408585,0.0001025726,0.0001401738,0.00001096697,0.0003017607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3739432,"threshold_uncertainty_score":0.429212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008187265647701976,"score_gpt":0.2352227689866391,"score_spread":0.2270355033389371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}