{"id":"W2055456683","doi":"10.1021/bp000107q","title":"Effect of PDI Overexpression on Recombinant Protein Secretion in CHO Cells","year":2000,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation","funders":"","keywords":"Protein disulfide-isomerase; Chinese hamster ovary cell; Endoplasmic reticulum; Secretion; Chaperone (clinical); Recombinant DNA; Chemistry; Biochemistry; Foldase; Isomerase; Cell biology; Fusion protein; Molecular biology; Biology; Receptor; Enzyme; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007754372,0.0007579857,0.0008672192,0.0003170242,0.0002982029,0.0008529279,0.0004612889,0.00052921,0.001086651],"category_scores_gemma":[0.0004540129,0.0003053076,0.0005745063,0.0006871838,0.0004303208,0.0004612702,0.0005402716,0.0009116295,0.00081118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006932839,"about_ca_system_score_gemma":0.0004591704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392365,"about_ca_topic_score_gemma":0.001079812,"domain_scores_codex":[0.9989573,0.0002289538,0.0002656521,0.0001661088,0.0002338501,0.0001480491],"domain_scores_gemma":[0.9995199,0.0001361328,0.00008320504,0.00009943514,0.00009082107,0.00007050679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002798732,0.00009389798,0.0001032949,0.00006460818,0.00001170821,0.00006558775,0.00004811383,0.00004783603,0.9985682,0.00007567217,0.00004255022,0.0005987838],"study_design_scores_gemma":[0.0000302042,0.0003129473,0.0006823328,0.000005254883,0.00002165923,0.0000757443,0.00002635756,0.000492015,0.9960932,0.00001537589,0.002239405,0.000005623003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880745,0.002876552,0.003619819,0.0002804411,0.0001871197,0.0001624227,0.00129927,0.0001967734,0.00330309],"genre_scores_gemma":[0.9763822,0.002707904,0.01001021,0.0002121318,0.00004141167,0.0002603884,0.003795929,0.0001608707,0.006428896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392365,"threshold_uncertainty_score":0.005030096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002611274721546989,"score_gpt":0.2326437999979687,"score_spread":0.2300325252764217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}