{"id":"W2055456683","doi":"10.1021/bp000107q","title":"Effect of PDI Overexpression on Recombinant Protein Secretion in CHO Cells","year":2000,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation","funders":"","keywords":"Protein disulfide-isomerase; Chinese hamster ovary cell; Endoplasmic reticulum; Secretion; Chaperone (clinical); Recombinant DNA; Chemistry; Biochemistry; Foldase; Isomerase; Cell biology; Fusion protein; Molecular biology; Biology; Receptor; Enzyme; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317531,0.0001723115,0.0001969647,0.00008697483,0.00003469763,0.000005959402,0.0002029914,0.0004895173,0.0001966917],"category_scores_gemma":[0.00004643505,0.0001373805,0.00007418855,0.0001210638,0.0002047421,0.000002903808,0.00006215413,0.0001460087,0.00002154634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001395089,"about_ca_system_score_gemma":0.00002245966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001215919,"about_ca_topic_score_gemma":0.000002377974,"domain_scores_codex":[0.9989353,0.0001149004,0.0002089538,0.0003818004,0.0001039354,0.00025513],"domain_scores_gemma":[0.9994161,0.00001233026,0.00008763358,0.0004200271,0.00001475603,0.00004920411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002083013,0.0002777686,0.0009625561,0.0001172368,0.00001489519,0.00001852074,0.000007471603,0.00002471485,0.9119411,0.0001246053,0.0005604765,0.0838676],"study_design_scores_gemma":[0.00118411,0.002795886,0.0003346188,0.0002683517,0.000006381424,0.000003959097,0.000005170092,0.00005906348,0.9880523,0.00002420781,0.007122883,0.0001430893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981025,0.000371535,0.000005247634,0.0001409884,0.00005062787,0.0007403536,0.00004277439,0.00003205319,0.0005138793],"genre_scores_gemma":[0.9989854,0.000168761,0.0001101563,0.00001707535,0.00002335485,0.0002606429,0.0001114438,0.00001697155,0.0003062604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08372451,"threshold_uncertainty_score":0.5602216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002611274721546989,"score_gpt":0.2326437999979687,"score_spread":0.2300325252764217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}