{"id":"W2055460844","doi":"10.1038/ncomms4303","title":"IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Natural Science Foundation of China","keywords":"IRF8; Pressure overload; Innate immune system; Calcineurin; Muscle hypertrophy; Immune system; Cell biology; Biology; Immunology; Medicine; Internal medicine; Transcription factor; Endocrinology; Cardiac hypertrophy; Gene; Biochemistry; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004171781,0.0001613831,0.0001554188,0.00002617012,0.0002799717,0.00004033494,0.000857497,0.0003879362,0.000006808777],"category_scores_gemma":[0.0007982049,0.0001596126,0.0001242178,0.0001118049,0.0001329444,0.000004968989,0.0004592327,0.0006050246,0.000007329868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001285783,"about_ca_system_score_gemma":0.00003268545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004885062,"about_ca_topic_score_gemma":0.000005086635,"domain_scores_codex":[0.9987295,0.0003343542,0.0002294778,0.0003317628,0.000145191,0.0002297715],"domain_scores_gemma":[0.9982646,0.0001889595,0.00009377216,0.001202924,0.0001468234,0.0001028848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001377788,0.00007974207,0.001634831,0.00000892395,0.00002118075,4.398784e-7,0.00003122799,0.0004621899,0.9884531,0.0008963365,0.007621537,0.0007766685],"study_design_scores_gemma":[0.0003067316,0.00008376088,0.0001946566,0.00004750509,0.00005558183,0.000006186966,0.00005281379,0.00293713,0.8679767,0.0003940311,0.1275547,0.000390224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578446,0.0233134,0.01231209,0.001322119,0.0002196313,0.0002734731,0.0001449288,0.0001235364,0.004446252],"genre_scores_gemma":[0.9898957,0.0004395013,0.007909943,0.0005984364,0.00020314,0.00003765362,0.0007917194,0.00003061957,0.00009331327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1204765,"threshold_uncertainty_score":0.6508814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735887761316448,"score_gpt":0.2839505387672409,"score_spread":0.2665916611540765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}