{"id":"W2055467504","doi":"10.1038/cdd.2013.96","title":"Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice","year":2013,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; St. Paul's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; CIHR Skin Research Training Centre; Canadian Institutes of Health Research","keywords":"Wound healing; Inflammation; Knockout mouse; Granzyme B; Perforin; Extracellular matrix; Fibronectin; Granzyme; Granzyme A; Apolipoprotein E; Immunology; Cell biology; Medicine; Biology; Pathology; Immune system; Internal medicine; T cell; CD8; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007970898,0.0001515568,0.0001380967,0.00006970154,0.00006925593,0.00007578052,0.00007317121,0.0001711407,0.00001199479],"category_scores_gemma":[0.00002336534,0.0001381436,0.00003196959,0.0000539383,0.00002380384,0.00001166669,0.00007786263,0.00006897419,0.00001052774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009994511,"about_ca_system_score_gemma":0.00001558554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001748792,"about_ca_topic_score_gemma":0.00006938668,"domain_scores_codex":[0.9991819,0.00004792905,0.0001820999,0.0002983432,0.00006994844,0.0002198413],"domain_scores_gemma":[0.9996157,0.00000844308,0.00005061439,0.0001667766,0.00004461303,0.0001138808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004965431,0.00004635988,0.00615157,0.00003363955,0.00001159046,9.629235e-7,0.00004087125,7.687145e-7,0.991873,0.0007841549,0.0001802414,0.0008271841],"study_design_scores_gemma":[0.001146878,0.0002355416,0.01719839,0.00002395045,0.00002734341,0.000003628926,0.00006381777,0.0003982203,0.9767863,0.002768309,0.001125849,0.0002217415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980732,0.01335492,0.004998494,0.0001396915,0.00006252826,0.0006333139,0.00001232351,0.00001009586,0.0000566173],"genre_scores_gemma":[0.9978497,0.0002722396,0.0005918211,0.00007466118,0.00007564701,0.0001021318,0.0001378461,0.00001361903,0.000882309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01711771,"threshold_uncertainty_score":0.5633334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005889960586202076,"score_gpt":0.2125545121092795,"score_spread":0.2066645515230774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}