{"id":"W2055519354","doi":"10.1038/gene.2012.12","title":"The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease","year":2012,"lang":"en","type":"review","venue":"Genes and Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":200,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Biology; Genetics; IGHV@; Germline; Locus (genetics); Haplotype; Gene; Antibody Repertoire; Immunoglobulin heavy chain; Antibody; Genome; Genetic variation; Copy-number variation; Computational biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0007174721,0.0004620683,0.0008647253,0.00008750038,0.002950788,0.0001193484,0.0009100935,0.0004563055,0.00003827181],"category_scores_gemma":[0.00008301008,0.0003206967,0.0001681677,0.0001232469,0.000600445,0.0001011358,0.0008546916,0.0004726326,0.00003807693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003748381,"about_ca_system_score_gemma":0.0002003937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002724271,"about_ca_topic_score_gemma":0.00003000316,"domain_scores_codex":[0.9974915,0.0006722301,0.0007106449,0.0005149801,0.00002402116,0.0005866133],"domain_scores_gemma":[0.9970355,0.0006321253,0.0004351372,0.001735803,0.00009308872,0.00006831705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003256739,0.0001163662,0.0000527667,0.001262466,0.0004847586,2.615067e-7,0.00009553073,5.665439e-8,0.008992432,0.0009239843,0.0004166664,0.9876221],"study_design_scores_gemma":[0.0004362221,0.00006723669,0.001350291,0.0003779251,0.001414772,0.0000902718,0.00004906325,0.000001452515,0.00003553707,0.0008639555,0.994931,0.0003822554],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006108197,0.9958423,0.0006658317,0.0003294412,0.0005611078,0.001074587,0.000841517,0.00004677421,0.00002765103],"genre_scores_gemma":[0.002552765,0.9924234,0.0001323625,0.00004604755,0.0001418939,0.0002197227,0.003339615,0.00005108846,0.00109317],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9945143,"threshold_uncertainty_score":0.9999245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06282429185020813,"score_gpt":0.3170290996353435,"score_spread":0.2542048077851353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}