{"id":"W2055519354","doi":"10.1038/gene.2012.12","title":"The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease","year":2012,"lang":"en","type":"review","venue":"Genes and Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":200,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Biology; Genetics; IGHV@; Germline; Locus (genetics); Haplotype; Gene; Antibody Repertoire; Immunoglobulin heavy chain; Antibody; Genome; Genetic variation; Copy-number variation; Computational biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001548421,0.001303043,0.00227155,0.001615537,0.0002437873,0.001386795,0.001824303,0.002180118,0.002308103],"category_scores_gemma":[0.001811319,0.0003905313,0.0004141218,0.002508631,0.001394948,0.002109804,0.0009187813,0.002810872,0.001921889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009259105,"about_ca_system_score_gemma":0.001509045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001051854,"about_ca_topic_score_gemma":0.001629789,"domain_scores_codex":[0.9996259,0.0000589755,0.00005232689,0.0001009124,0.0001269245,0.00003494722],"domain_scores_gemma":[0.9988361,0.0005633717,0.0001689104,0.00003678025,0.0002497639,0.0001450155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001657838,0.00003936579,0.0005110329,0.006854156,0.0001113987,0.0003409273,0.00003773663,0.0003042952,0.001974707,0.002863607,0.06577068,0.9210264],"study_design_scores_gemma":[0.00003927896,0.00005770506,0.001869222,0.002326191,0.0001845622,0.002599281,0.00009241798,0.0001287761,0.0004174979,0.005067697,0.9871793,0.00003813028],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007510067,0.9981176,0.0002087222,0.000758253,0.0005492814,0.000001326188,0.00002026986,0.000007952174,0.0002615117],"genre_scores_gemma":[0.0005153437,0.9972072,0.0002524056,0.0006163041,0.001065239,0.000002965557,0.00004611432,0.000002297259,0.000292111],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002308103,"threshold_uncertainty_score":0.008188963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06282429185020813,"score_gpt":0.3170290996353435,"score_spread":0.2542048077851353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}