{"id":"W2055528775","doi":"10.1016/j.bbrc.2004.11.031","title":"Coordinate regulation of glutathione metabolism in astrocytes by Nrf2","year":2004,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Glutathione; Inducer; Biochemistry; Buthionine sulfoximine; Chemistry; Glutamate receptor; GPX1; Oxidative stress; Glycine; Glutamine; Gene expression; Metabolism; Biology; Amino acid; Enzyme; Gene; Glutathione peroxidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003816821,0.0001054209,0.0001707537,0.00007932939,0.00009858248,0.00001395187,0.0005599519,0.0001639388,0.000003858047],"category_scores_gemma":[0.0004186028,0.00009516926,0.0000507226,0.0003425422,0.001126618,0.000006085897,0.000577656,0.0002774486,0.000005320634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002790595,"about_ca_system_score_gemma":0.00007196078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001219974,"about_ca_topic_score_gemma":0.00001502524,"domain_scores_codex":[0.9988242,0.0001948556,0.0002424149,0.0002815352,0.0001919473,0.0002650682],"domain_scores_gemma":[0.9987783,0.0001285467,0.00004955764,0.000745126,0.0002044228,0.00009403064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007850186,0.0003075571,0.0001244655,0.000009725442,0.00001478364,1.346634e-7,0.00002457245,0.000001466056,0.9927943,0.005517513,0.0004215806,0.0007054062],"study_design_scores_gemma":[0.0006514838,0.0001650336,0.005307604,0.00002391287,0.000005069572,0.000002848454,0.00004966844,0.00004066662,0.9837984,0.004045942,0.00580161,0.0001077107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944927,0.002853921,0.0001719039,0.001857766,0.00001423889,0.0001697718,0.00003697247,0.000007880943,0.0003948798],"genre_scores_gemma":[0.9955723,0.001099446,0.002868722,0.00003662217,0.00004942526,0.00004645608,0.0002606806,0.000009999794,0.00005634621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008995844,"threshold_uncertainty_score":0.4151072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03792268788791556,"score_gpt":0.3456591991774777,"score_spread":0.3077365112895621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}