{"id":"W2055546317","doi":"10.1002/prot.23243","title":"Kinetic consequences of native state optimization of surface‐exposed electrostatic interactions in the Fyn SH3 domain","year":2011,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Folding (DSP implementation); Contact order; Chemical physics; Protein folding; Chemistry; FYN; SH3 domain; Charge density; Kinetics; Electrostatics; Native state; Crystallography; Physical chemistry; Physics; Biochemistry; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003000188,0.0002445807,0.0002583757,0.0001062009,0.0002227156,0.0003554164,0.0001880494,0.0002021796,0.0004558779],"category_scores_gemma":[0.0005538999,0.0001125256,0.0001898128,0.0001481477,0.0002687377,0.000289812,0.0001631486,0.0003864314,0.00007687974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005130082,"about_ca_system_score_gemma":0.0003047518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001772898,"about_ca_topic_score_gemma":0.001739166,"domain_scores_codex":[0.9998916,0.00001946061,0.00001019295,0.00001887242,0.00002862443,0.00003112045],"domain_scores_gemma":[0.9998086,0.00007988983,0.00004450149,0.00001515306,0.00002701129,0.00002481425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007151258,0.0002867222,0.007179717,0.0000826987,0.00006008075,0.0003411468,0.0001354736,0.07783117,0.9056651,0.001637391,0.0001517914,0.005913576],"study_design_scores_gemma":[0.00006119753,0.0006202662,0.0108751,0.000009330029,0.00005263361,0.0001880784,0.0001268042,0.3449232,0.6419304,0.0006041423,0.0005638112,0.00004497588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992742,0.00003086795,0.0005450581,0.000009058316,0.000001593818,0.000001893475,0.00001466464,0.00001110248,0.0001116605],"genre_scores_gemma":[0.999373,0.00003164555,0.0004693499,0.000005247712,4.830001e-7,0.000003080684,0.00003445068,0.000007678584,0.00007500234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001772898,"threshold_uncertainty_score":0.003722131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010935152997354,"score_gpt":0.2209423517287769,"score_spread":0.2108330001988034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}