{"id":"W2055552718","doi":"10.1016/j.bbrc.2003.10.042","title":"Functionally important amino acids in Saccharomyces cerevisiae aspartate kinase","year":2003,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Saccharomyces cerevisiae; Biochemistry; Kinase; Amino acid; Enzyme; Mutagenesis; Biosynthesis; Site-directed mutagenesis; Biology; Phosphorylation; Chemistry; Mutation; Yeast; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017844,0.0005855436,0.0004251966,0.0002691397,0.000485363,0.0005257169,0.000444748,0.000624229,0.0006960771],"category_scores_gemma":[0.0003659112,0.0002455305,0.0002588091,0.0003094135,0.0004049819,0.0005381049,0.0003464416,0.0005550258,0.0003832788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005841411,"about_ca_system_score_gemma":0.000409386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009497386,"about_ca_topic_score_gemma":0.0008872075,"domain_scores_codex":[0.9999007,0.00002204281,0.00001674255,0.00001658807,0.00002731923,0.00001668581],"domain_scores_gemma":[0.9997668,0.00005931538,0.00005589494,0.00001876398,0.00002892709,0.00007029864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001766649,0.00006367359,0.00132737,0.0001435926,0.00001473256,0.001187617,0.00008942224,0.001998299,0.9862299,0.002523122,0.00008941789,0.004566231],"study_design_scores_gemma":[0.00008559584,0.0003680422,0.005582244,0.00001699443,0.00005466813,0.001304621,0.0001497279,0.002419852,0.9848415,0.002107728,0.00304266,0.00002630631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942003,0.001675398,0.002583979,0.0001581924,0.00005521996,0.00001065866,0.0001609608,0.00005457887,0.00110071],"genre_scores_gemma":[0.9968336,0.0005961655,0.001496345,0.00004341097,0.00001324694,0.000004993164,0.0003228309,0.00001613191,0.0006733023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009497386,"threshold_uncertainty_score":0.004238248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06291261842297613,"score_gpt":0.3446696225444703,"score_spread":0.2817570041214942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}