{"id":"W2055555255","doi":"10.1186/1750-1326-6-59","title":"Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease","year":2011,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC; CHDI Foundation","keywords":"Neuroscience; Huntingtin; Huntington's disease; Neuropathology; Huntingtin Protein; Neurodegeneration; Pathology; Medicine; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001667192,0.0003187501,0.0002524922,0.0001783143,0.0001553273,0.00006160147,0.0005354752,0.00008721004,0.0000162581],"category_scores_gemma":[0.0003969754,0.0002863078,0.000105119,0.0003772496,0.0001556794,0.0001325668,0.0001323288,0.0002641503,0.000009042076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002346502,"about_ca_system_score_gemma":0.00007842886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002394184,"about_ca_topic_score_gemma":0.0002994037,"domain_scores_codex":[0.9967741,0.00103989,0.0004014633,0.0008854576,0.0005254806,0.0003736537],"domain_scores_gemma":[0.9986652,0.00005884875,0.0003168051,0.0007368324,0.0001104326,0.0001118858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115217,0.0003973846,0.00138187,0.0000134884,0.000001628994,0.0001274311,0.0006451752,0.006013722,0.9907524,0.0002370058,0.00001495217,0.0002997456],"study_design_scores_gemma":[0.0004259957,0.0001071053,0.01754274,0.00002005678,0.0000527668,0.000001935002,0.00004799428,0.02334071,0.95798,0.0002316597,0.00000321651,0.0002458617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941642,0.00005223243,0.003794792,0.000358724,0.0001721249,0.001029314,0.0003247346,0.00006271037,0.00004115072],"genre_scores_gemma":[0.9961894,0.00001943298,0.0007940051,0.002535378,0.00005315256,0.000276137,0.00005621543,0.0000580485,0.0000182413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03277242,"threshold_uncertainty_score":0.9999589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08997589521327133,"score_gpt":0.2696594256191619,"score_spread":0.1796835304058906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}