{"id":"W2055575181","doi":"10.1016/j.yexcr.2014.09.003","title":"DNA double strand break responses and chromatin alterations within the aging cell","year":2014,"lang":"en","type":"review","venue":"Experimental Cell Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Biology; Telomere; Senescence; Chromatin; Cell biology; DNA damage; DNA repair; Heterochromatin; Context (archaeology); Cell cycle; DNA; Chromatin remodeling; Cell cycle checkpoint; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001921156,0.0004509578,0.001100084,0.0004071842,0.0007593336,0.0002998881,0.0004122205,0.000235579,0.0003991113],"category_scores_gemma":[0.00004880547,0.000291213,0.0002306817,0.0005059955,0.0005829862,0.0001048234,0.0002784429,0.001218259,0.0002078044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178306,"about_ca_system_score_gemma":0.0006997249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246088,"about_ca_topic_score_gemma":0.00001984675,"domain_scores_codex":[0.9959816,0.0008870416,0.0006806023,0.000732825,0.001059416,0.0006584737],"domain_scores_gemma":[0.9975241,0.0009584443,0.000171719,0.0008631644,0.0001149509,0.0003675684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00354755,0.005798141,0.0001847788,0.133987,0.000939409,0.001724388,0.04524104,0.000003651807,0.2664025,0.002190663,0.07838629,0.4615945],"study_design_scores_gemma":[0.001861405,0.0006601934,0.00001129599,0.005179365,0.0001449752,0.0002561899,0.002263771,0.00003239219,0.09593655,0.00001148289,0.8931835,0.0004588195],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01123181,0.9758577,0.00000493979,0.0001440763,0.000164599,0.001991979,0.00002554282,0.0000553866,0.01052401],"genre_scores_gemma":[0.05466389,0.9242874,0.0002660282,0.0000764877,0.0005101274,0.0003517713,0.0001293676,0.0001096136,0.01960525],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8147973,"threshold_uncertainty_score":0.999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1539195061094478,"score_gpt":0.4615086242106745,"score_spread":0.3075891181012267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}