{"id":"W2055583355","doi":"10.1371/journal.pbio.0040021","title":"Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing","year":2006,"lang":"en","type":"article","venue":"PLoS Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"RNA splicing; Intron; Biology; Exon; Alternative splicing; Polypyrimidine tract; Precursor mRNA; Exonic splicing enhancer; Minigene; RNA-binding protein; Messenger RNA; Exon skipping; SR protein; Splice site mutation; Genetics; Protein splicing; Cell biology; Molecular biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450719,0.0002339178,0.0001701947,0.00009807845,0.0001405728,0.0001438778,0.0001183923,0.0002172232,0.002279036],"category_scores_gemma":[0.0001732644,0.0001090696,0.0002352578,0.00006765474,0.0001943721,0.00009245057,0.0001594749,0.0003618042,0.0004824506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463185,"about_ca_system_score_gemma":0.0001397136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005906873,"about_ca_topic_score_gemma":0.001010773,"domain_scores_codex":[0.9999051,0.0000213161,0.000005196111,0.00002086465,0.00002908305,0.00001843038],"domain_scores_gemma":[0.999866,0.00005332653,0.00002542755,0.00001214331,0.00001085876,0.00003222511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001124487,0.00002522722,0.0005023088,0.00003131991,0.000004525118,0.00004874583,0.000009895583,0.0002023806,0.9972613,0.0001306776,0.00003357845,0.001637527],"study_design_scores_gemma":[0.00003280258,0.0003970797,0.01089038,0.000009577079,0.00001863775,0.0003341687,0.00005721652,0.004467302,0.9806333,0.0002248908,0.002924992,0.000009681547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916711,0.0005222379,0.005645609,0.00004524199,0.0000196007,0.00001573962,0.0000854036,0.00008270784,0.001912375],"genre_scores_gemma":[0.9920608,0.0002168325,0.006149602,0.00006444912,0.000007259327,0.00001299211,0.0002029583,0.00002081996,0.00126436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002279036,"threshold_uncertainty_score":0.007624149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01524764449769351,"score_gpt":0.2818408122372391,"score_spread":0.2665931677395456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}