{"id":"W2055596436","doi":"10.1074/jbc.m704867200","title":"XRCC1 Stimulates Polynucleotide Kinase by Enhancing Its Damage Discrimination and Displacement from DNA Repair Intermediates","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Alberta Cancer Foundation","keywords":"XRCC1; DNA; Biochemistry; DNA repair; DNA damage; Polynucleotide; Phosphatase; Biology; Enzyme; Molecular biology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054615,0.0001912304,0.0002310189,0.00002068954,0.00005289956,0.0000254353,0.000185581,0.0002432633,0.00007847605],"category_scores_gemma":[0.0005337894,0.0001428698,0.0001430624,0.00004280336,0.00008947081,0.00001101852,0.0001670154,0.0001866636,0.000001820715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003823174,"about_ca_system_score_gemma":0.00002200476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004328364,"about_ca_topic_score_gemma":0.000003904282,"domain_scores_codex":[0.9987701,0.00003790699,0.0004969575,0.0002841887,0.0001611948,0.0002497216],"domain_scores_gemma":[0.9991368,0.00008237577,0.0003226925,0.0001594857,0.0001031755,0.0001954706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002380116,0.0001066686,0.004087928,0.00002428535,0.00006394289,0.00003633581,0.00003377248,0.000001764899,0.994176,0.000002646752,0.0004027097,0.0008258836],"study_design_scores_gemma":[0.0005371268,0.0003824698,0.00595543,0.00005756592,0.00003375731,0.00003091414,0.00030457,0.00006038667,0.9913171,0.00008250202,0.001061168,0.0001769888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966727,0.001729251,0.001132621,0.00008209316,0.0001044792,0.00006640986,0.00003763918,0.00001665073,0.0001581284],"genre_scores_gemma":[0.997723,0.0002760419,0.001220657,0.0001403728,0.0003285433,0.000001570801,0.0001174657,0.00001341395,0.0001789409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002858929,"threshold_uncertainty_score":0.5826062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009807020115647911,"score_gpt":0.2531799569740648,"score_spread":0.2433729368584168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}