{"id":"W2055658079","doi":"10.1097/yic.0b013e32835b0814","title":"Is it time to shift to better characterization of patients in trials assessing novel antidepressants? An example of two relapse prevention studies with agomelatine","year":2012,"lang":"en","type":"article","venue":"International Clinical Psychopharmacology","topic":"Mental Health Research Topics","field":"Psychology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Servier; Sanofi; AstraZeneca","keywords":"Agomelatine; Medicine; Internal medicine; Oncology; Psychology; Antidepressant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004254551,0.0001596186,0.0006777039,0.0003855643,0.00002798486,0.000009802772,0.000335088,0.0001306853,0.004853414],"category_scores_gemma":[0.0005427665,0.0001395509,0.00009006116,0.00026826,0.00009968466,0.000375659,0.0001263716,0.0002931063,0.0002290255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008252073,"about_ca_system_score_gemma":0.00004050452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000130417,"about_ca_topic_score_gemma":0.00002768295,"domain_scores_codex":[0.9956891,0.001165364,0.001907413,0.0004413649,0.0004445697,0.0003521825],"domain_scores_gemma":[0.9970828,0.001329368,0.0007636502,0.0002604459,0.0003248668,0.0002388257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006054349,0.006370148,0.9328992,0.00006084966,0.0005235896,0.000003214598,0.003142171,0.00001045529,0.01920732,0.0002052017,0.003430909,0.02809255],"study_design_scores_gemma":[0.007654911,0.001177118,0.9853813,0.000122577,0.00004171378,0.000001042828,0.00006072008,0.00004029624,0.000817696,0.0001022692,0.004467521,0.0001328371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99165,0.00001650198,0.001068953,0.002897124,0.002313609,0.001111783,0.000126437,0.0000107056,0.0008048585],"genre_scores_gemma":[0.9921697,0.00001725992,0.002163474,0.004028284,0.0005594412,0.0001328653,0.0001194569,0.00002440067,0.0007850839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05248206,"threshold_uncertainty_score":0.9960563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4378777859731027,"score_gpt":0.6243300459637704,"score_spread":0.1864522599906677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}