{"id":"W2055695109","doi":"10.1158/1078-0432.ccr-05-2130","title":"Irinotecan Inactivation Is Modulated by Epigenetic Silencing of<i>UGT1A1</i>in Colon Cancer","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Hôtel-Dieu de Québec","funders":"","keywords":"Irinotecan; Epigenetics; Colorectal cancer; Gene silencing; Cancer; Medicine; Cancer research; Biology; Oncology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006715619,0.0002120151,0.0002055283,0.0001796934,0.0001309795,0.0001774407,0.0000877428,0.0001207559,0.0007406404],"category_scores_gemma":[0.00008438767,0.00008888178,0.0001375568,0.0001631162,0.0001779091,0.00007277323,0.00007542127,0.0002208701,0.0001822635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003650977,"about_ca_system_score_gemma":0.0001769586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001579595,"about_ca_topic_score_gemma":0.001606607,"domain_scores_codex":[0.9999393,0.000009829162,0.000004745595,0.00001440227,0.00001524445,0.00001642443],"domain_scores_gemma":[0.9999526,0.000005980993,0.00001630187,0.000006266951,0.00000613992,0.00001268915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001503324,0.0000136119,0.001044464,0.00002152473,0.000005636421,0.00005130633,0.00001116341,0.00005807905,0.9973833,0.0000280057,0.0000289124,0.001203726],"study_design_scores_gemma":[0.00001405644,0.0003762681,0.04055886,0.000003712355,0.00002921172,0.0004416337,0.00002477167,0.0007645296,0.9561262,0.00002159449,0.001636094,0.00000321956],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978696,0.0009087806,0.0004654226,0.0000369349,0.000006393515,0.000009733599,0.0001459532,0.00004001843,0.0005171125],"genre_scores_gemma":[0.9985966,0.0003994033,0.0002556585,0.00001521481,0.00000242162,0.000007991959,0.0002459793,0.000005088532,0.000471661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001579595,"threshold_uncertainty_score":0.003140748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1031414875995283,"score_gpt":0.4858927950243436,"score_spread":0.3827513074248152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}