{"id":"W2055705536","doi":"10.1002/smll.201001428","title":"Monitoring of an ATP‐Binding Aptamer and its Conformational Changes Using an α‐Hemolysin Nanopore","year":2010,"lang":"en","type":"article","venue":"Small","topic":"Nanopore and Nanochannel Transport Studies","field":"Engineering","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Nanjing University; National Natural Science Foundation of China","keywords":"Aptamer; Nanopore; Biophysics; Chemistry; Conformational change; DNA; Oligonucleotide; Molecular beacon; Adenosine triphosphate; Biochemistry; Biology; Nanotechnology; Materials science; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586358,0.0001543696,0.0001673989,0.0001190744,0.0001637867,0.0001576603,0.0001825045,0.0002444791,0.000277766],"category_scores_gemma":[0.0002143017,0.00008685424,0.0001046712,0.00009353829,0.0001688312,0.0003231905,0.0001262619,0.000245873,0.00008956806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003269946,"about_ca_system_score_gemma":0.0001421587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006707844,"about_ca_topic_score_gemma":0.0006914872,"domain_scores_codex":[0.9999012,0.0000118883,0.000007027092,0.00003490332,0.00003221672,0.00001282285],"domain_scores_gemma":[0.9998719,0.00004625615,0.00003206201,0.000007775865,0.00002322483,0.00001879886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001727539,0.00000883687,0.0001104008,0.000008919089,0.000001382177,0.00001619905,0.00001057962,0.00007156162,0.9991848,0.00003440457,0.000006740442,0.000528932],"study_design_scores_gemma":[0.000002467153,0.00006078302,0.0009055854,0.000001211401,0.00000302281,0.00007587234,0.00001182807,0.002679409,0.9960163,0.00002167932,0.0002187311,0.000003098085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812508,0.0002613939,0.0178916,0.00003305191,0.00001229635,0.00001903867,0.00009736943,0.000073842,0.0003606417],"genre_scores_gemma":[0.9809117,0.0002331213,0.01783638,0.00003180887,0.000003815024,0.0000361491,0.0001211266,0.00001079048,0.0008149751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006707844,"threshold_uncertainty_score":0.002372503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03576477333668036,"score_gpt":0.2430096764509408,"score_spread":0.2072449031142605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}