{"id":"W2055709087","doi":"10.1093/molehr/gau060","title":"NLRP7 inter-domain interactions: the NACHT-associated domain is the physical mediator for oligomeric assembly","year":2014,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Gestational Trophoblastic Disease Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Rheinische Friedrich-Wilhelms-Universität Bonn","keywords":"Pyrin domain; Biology; Missense mutation; In silico; Leucine-rich repeat; Cell biology; Protein domain; Mutation; Genetics; Gene; Receptor; Inflammasome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151596,0.0004725582,0.0003523271,0.0001689317,0.0002192039,0.0003277996,0.0003600356,0.000598673,0.00107558],"category_scores_gemma":[0.0002464116,0.0001459665,0.0005423609,0.0001698165,0.0002832156,0.0002398359,0.0003248453,0.0005230615,0.000476364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000335815,"about_ca_system_score_gemma":0.0001324569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005251822,"about_ca_topic_score_gemma":0.000499939,"domain_scores_codex":[0.9998372,0.00002812949,0.00001229006,0.0000345901,0.00006870416,0.00001912411],"domain_scores_gemma":[0.9998796,0.00003387195,0.00004043201,0.00001423431,0.00001589733,0.00001602753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001011932,0.00003198339,0.001086607,0.000103444,0.00002668309,0.000721537,0.00003647173,0.001118319,0.9948542,0.0003099178,0.00006441362,0.001545322],"study_design_scores_gemma":[0.00003055441,0.0001771933,0.008330784,0.00001525178,0.00007858918,0.002781862,0.00008712363,0.01752355,0.9674124,0.0002879546,0.00325528,0.00001953219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891213,0.0009053201,0.008250198,0.0001133977,0.00001873197,0.00002663697,0.0003354566,0.0001634029,0.001065575],"genre_scores_gemma":[0.9934825,0.0003308498,0.004800297,0.00003925686,0.000004026233,0.00001428678,0.0007416288,0.00002841975,0.0005586308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107558,"threshold_uncertainty_score":0.003598154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414069118076707,"score_gpt":0.3022637240474308,"score_spread":0.2881230328666637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}