{"id":"W2055709087","doi":"10.1093/molehr/gau060","title":"NLRP7 inter-domain interactions: the NACHT-associated domain is the physical mediator for oligomeric assembly","year":2014,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Gestational Trophoblastic Disease Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Rheinische Friedrich-Wilhelms-Universität Bonn","keywords":"Pyrin domain; Biology; Missense mutation; In silico; Leucine-rich repeat; Cell biology; Protein domain; Mutation; Genetics; Gene; Receptor; Inflammasome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005992176,0.0002024897,0.000263278,0.00008172776,0.0004863916,0.00004686728,0.0001471595,0.00003552967,0.00002470242],"category_scores_gemma":[0.001331432,0.0001269931,0.0002523657,0.0002718576,0.0002152566,0.00005579471,0.00006540478,0.0002266263,0.00005011227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001395347,"about_ca_system_score_gemma":0.00004393761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002327021,"about_ca_topic_score_gemma":0.00001161856,"domain_scores_codex":[0.998268,0.0002207456,0.0002863517,0.0005488452,0.0004216328,0.0002544235],"domain_scores_gemma":[0.9984732,0.0002289203,0.0001966665,0.0007104949,0.0003238014,0.00006686766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007991963,0.002541752,0.001199242,0.0003281028,0.002785296,0.00002824661,0.01255447,0.0001572822,0.858146,0.04467823,0.06305907,0.01372318],"study_design_scores_gemma":[0.01163853,0.004204031,0.1924509,0.0007193231,0.003960066,0.0002927152,0.01521271,0.003472698,0.09837928,0.3058665,0.3619436,0.001859633],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966054,0.0001206732,0.0111322,0.02014935,0.0005942012,0.000991341,0.0000115035,0.00009552482,0.0008512386],"genre_scores_gemma":[0.9961548,0.000003693047,0.0005532829,0.0009385759,0.001006466,0.0004611316,0.00006902053,0.00004371682,0.0007692996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7597666,"threshold_uncertainty_score":0.5178629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414069118076707,"score_gpt":0.3022637240474308,"score_spread":0.2881230328666637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}