{"id":"W2055734284","doi":"10.1053/j.gastro.2014.01.022","title":"Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer","year":2014,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":230,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Cancer Care Ontario","funders":"Cancer Council Victoria; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health","keywords":"MUTYH; Medicine; Colorectal cancer; Oncology; Cancer; Family history; Internal medicine; Population; Mutation; Genetics; Germline mutation; Gene; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361343,0.0001113825,0.0004902296,0.0001431993,0.000007860001,4.038281e-7,0.00005667482,0.00006831404,0.00003186304],"category_scores_gemma":[0.00007822682,0.00009445813,0.00004733046,0.00005814713,0.0005299352,0.00001557864,0.00002017359,0.0001029625,4.436022e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001669929,"about_ca_system_score_gemma":0.000233976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00290077,"about_ca_topic_score_gemma":0.01169034,"domain_scores_codex":[0.9991225,0.00006597093,0.0003052133,0.0001948187,0.0001136562,0.0001978245],"domain_scores_gemma":[0.9992839,0.00006809922,0.000292303,0.0001211861,0.0001742386,0.00006032081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004376542,0.00005376127,0.9519668,0.0001803228,0.000150744,3.173287e-7,0.00119156,0.000503544,0.04053055,0.000005554554,0.0001536647,0.0008866016],"study_design_scores_gemma":[0.005103525,0.004774475,0.9823546,0.0001167335,0.0003148073,0.000007624849,0.0002439201,0.001157939,0.005601287,0.00002701855,0.0002465798,0.00005149253],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977381,0.0006008401,0.00068177,0.00008055544,0.0002219751,0.000456249,0.0001250304,0.000005263254,0.00009026596],"genre_scores_gemma":[0.996431,0.00009518918,0.003064715,0.0001051599,0.00001988508,0.0002217446,0.000005694522,0.000017409,0.00003919112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03492926,"threshold_uncertainty_score":0.6523485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129099958412675,"score_gpt":0.264858894412517,"score_spread":0.2535678948283903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}