{"id":"W2055737936","doi":"10.1038/sj.mt.6300207","title":"Proteolytic Disassembly Is a Critical Determinant for Reovirus Oncolysis","year":2007,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Cancer cell; Biology; Cathepsin; Proteases; Oncolytic virus; In vitro; Cathepsin B; Reoviridae; Cell biology; Cell; Virology; Cancer; Virus; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328233,0.0002591807,0.0002159103,0.0001267433,0.0001246393,0.000365155,0.0001112964,0.000236421,0.0007604412],"category_scores_gemma":[0.0002157603,0.0001278653,0.0002230662,0.00006218212,0.0002005791,0.0002570209,0.0001503369,0.000362413,0.0003030583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520584,"about_ca_system_score_gemma":0.0001427258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003477719,"about_ca_topic_score_gemma":0.0003699674,"domain_scores_codex":[0.9998553,0.00002255684,0.00001404792,0.0000292958,0.00004396793,0.00003478691],"domain_scores_gemma":[0.9997528,0.00005351265,0.0001057283,0.00003073485,0.00002371262,0.0000334646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000448168,0.000006078746,0.0003462395,0.00000996715,0.000002065896,0.0000410801,0.000007974245,0.00003525852,0.9989977,0.00005606113,0.00000897286,0.0004437642],"study_design_scores_gemma":[0.000002201942,0.0001211432,0.0060824,0.000001626721,0.000005570434,0.0005375004,0.00001766186,0.0003121308,0.9921216,0.00003598871,0.0007598734,0.000002399314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953259,0.001179737,0.002628325,0.00004327109,0.000007406101,0.00001034697,0.0000661461,0.00003172995,0.0007072082],"genre_scores_gemma":[0.9984767,0.0002858454,0.000588582,0.00001286991,0.000003196966,0.000005858972,0.0001289659,0.00000984899,0.0004881289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007604412,"threshold_uncertainty_score":0.002543926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02598631644781741,"score_gpt":0.3687667869041328,"score_spread":0.3427804704563154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}