{"id":"W2055737936","doi":"10.1038/sj.mt.6300207","title":"Proteolytic Disassembly Is a Critical Determinant for Reovirus Oncolysis","year":2007,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Cancer cell; Biology; Cathepsin; Proteases; Oncolytic virus; In vitro; Cathepsin B; Reoviridae; Cell biology; Cell; Virology; Cancer; Virus; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007685656,0.0002865912,0.0002512642,0.0001092954,0.0001686632,0.0000588947,0.0004234519,0.0002456803,0.00005209854],"category_scores_gemma":[0.0001632334,0.0002653074,0.0003346032,0.0001999804,0.0001680116,0.000005384313,0.00006973444,0.0001291392,0.00003398287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004606298,"about_ca_system_score_gemma":0.0001233083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001113769,"about_ca_topic_score_gemma":0.00004933299,"domain_scores_codex":[0.9978036,0.0001042607,0.0003278094,0.0006397816,0.0003578067,0.0007667672],"domain_scores_gemma":[0.9986563,0.00006251146,0.00006164606,0.0007833592,0.0002124589,0.0002237609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00446367,0.0001868144,0.00008378923,0.00002269251,0.0001146379,0.00004141701,0.00006308755,0.000003750919,0.9417509,0.00008465314,0.0002710531,0.05291356],"study_design_scores_gemma":[0.001563523,0.004636028,0.0001231692,0.00001391308,0.00001719042,0.00001862452,0.00003974496,0.00005092503,0.9627484,0.000314259,0.0301337,0.0003405391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9441881,0.002873193,0.05052176,0.0007270581,0.00008203523,0.001129413,0.00002715697,0.00002900131,0.0004222788],"genre_scores_gemma":[0.9928221,0.0002771359,0.002614738,0.003021638,0.0002481141,0.0003083852,0.00004112493,0.0001017264,0.0005650187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05257302,"threshold_uncertainty_score":0.9999799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02598631644781741,"score_gpt":0.3687667869041328,"score_spread":0.3427804704563154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}