{"id":"W2055746941","doi":"10.1371/journal.pmed.0040249","title":"Beta-Catenin Signaling Plays a Disparate Role in Different Phases of Fracture Repair: Implications for Therapy to Improve Bone Healing","year":2007,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":389,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"School of Medicine, Stanford University","keywords":"DKK1; Bone healing; Wnt signaling pathway; Beta-catenin; Osteoblast; Signal transduction; Cell biology; Biology; Cancer research; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003814083,0.0001906586,0.0003287268,0.0001074888,0.00005586064,0.000004358348,0.0001462424,0.000100818,0.00002968988],"category_scores_gemma":[0.0001015168,0.0001398558,0.00008892328,0.0001430665,0.00005295259,0.000003526622,0.00003112682,0.00008547321,6.553594e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002933175,"about_ca_system_score_gemma":0.00004939456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003803796,"about_ca_topic_score_gemma":0.00003666538,"domain_scores_codex":[0.998702,0.00001810866,0.0004804806,0.0003540257,0.0001361739,0.000309225],"domain_scores_gemma":[0.9992903,0.00008303527,0.0001476767,0.0002319587,0.0001360789,0.000110891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004993674,0.0001473675,0.007657122,0.00003147201,0.00009900811,8.254286e-7,0.0003500135,0.0001086012,0.9882759,0.00002095779,0.001315179,0.001494147],"study_design_scores_gemma":[0.00179103,0.0006595472,0.007016293,0.0001313097,0.0000364533,0.000001818905,0.0001559365,0.00005038975,0.985428,0.0001839805,0.004365731,0.0001794848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843362,0.003753217,0.00925872,0.00176605,0.00008514658,0.0006614416,0.00002669796,0.00002251357,0.00009002948],"genre_scores_gemma":[0.9963499,0.0002042197,0.001438027,0.0009137048,0.0005190478,0.0001819216,0.0002030973,0.00002753108,0.0001625024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01201377,"threshold_uncertainty_score":0.5703154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02445526556076715,"score_gpt":0.3021168407881066,"score_spread":0.2776615752273395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}