{"id":"W2055776712","doi":"10.1038/embor.2008.155","title":"Rtt101 and Mms1 in budding yeast form a CUL4DDB1‐like ubiquitin ligase that promotes replication through damaged DNA","year":2008,"lang":"en","type":"article","venue":"EMBO Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Centre National de la Recherche Scientifique; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche","keywords":"DDB1; Ubiquitin ligase; Biology; DNA ligase; Cell division control protein 4; DNA replication; Ubiquitin; Eukaryotic DNA replication; Replication factor C; Control of chromosome duplication; Cell biology; DNA repair; Ribonucleotide reductase; Origin recognition complex; DNA; Genetics; Protein subunit; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003892542,0.0001773382,0.0001857788,0.00004446133,0.0001071524,0.00002321889,0.0000847216,0.0001625002,0.00001335471],"category_scores_gemma":[0.0002127216,0.0001772418,0.00006420761,0.0001007043,0.00006613869,0.00001976022,0.0001472324,0.0001024287,0.000003060038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002626016,"about_ca_system_score_gemma":0.00007295561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006397147,"about_ca_topic_score_gemma":0.0000605713,"domain_scores_codex":[0.9985022,0.00004026874,0.0003346818,0.0006800423,0.0001718849,0.0002709455],"domain_scores_gemma":[0.9988022,0.000007421964,0.0002246866,0.0008385269,0.00005142437,0.00007573331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002836706,0.0001037466,0.01479345,0.00003606702,0.00002322118,0.0006634918,0.0006797665,0.000002528938,0.980788,0.00007002405,0.001167914,0.001643429],"study_design_scores_gemma":[0.0002849382,0.0001295968,0.009089255,0.00004613948,0.00001146393,0.002452869,0.0001442728,0.00003429733,0.978012,0.0008648813,0.008686695,0.0002435882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958405,0.0003056579,0.0003306,0.0001199836,0.00011972,0.0003994266,0.000004023278,0.00004847469,0.002831587],"genre_scores_gemma":[0.9959103,0.0001461681,0.002269775,0.0001889503,0.00009769552,0.00008422307,0.0001241498,0.00003400991,0.00114473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007518781,"threshold_uncertainty_score":0.722771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141480368790693,"score_gpt":0.2588492667173503,"score_spread":0.2374344630294433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}