{"id":"W2055836967","doi":"10.1007/s00125-010-1758-0","title":"Reciprocal modulation of adult beta cell maturity by activin A and follistatin","year":2010,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Michael Smith Health Research BC; Stem Cell Network","keywords":"Follistatin; Endocrinology; Paracrine signalling; PDX1; Biology; Internal medicine; Autocrine signalling; Beta cell; Activin type 2 receptors; Cell biology; Downregulation and upregulation; Insulin; TGF beta signaling pathway; Islet; Cell culture; Receptor; Transforming growth factor; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004428475,0.0002988888,0.0003610548,0.0003414163,0.000174857,0.0008495697,0.0002798948,0.0003239518,0.001187849],"category_scores_gemma":[0.0005249195,0.000278363,0.0002706182,0.0001464483,0.0003508178,0.0006495694,0.0006357699,0.001263894,0.0003299259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863633,"about_ca_system_score_gemma":0.0002033312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000129398,"about_ca_topic_score_gemma":0.0002308776,"domain_scores_codex":[0.9997496,0.00006692952,0.00002510431,0.00003643009,0.00003796394,0.00008386072],"domain_scores_gemma":[0.9994425,0.0001523651,0.0001079901,0.00005820029,0.00004297298,0.0001959869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001215023,0.00003801405,0.0008487236,0.00003414415,0.00001182052,0.00008984459,0.00003279292,0.00004459016,0.9927873,0.0004205584,0.00003932074,0.004437832],"study_design_scores_gemma":[0.0002884892,0.001481538,0.08200052,0.00003487068,0.0001167156,0.0006389238,0.0003913961,0.001140572,0.9085782,0.001076902,0.004233551,0.00001817835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906489,0.005209783,0.001284178,0.0001846382,0.00006116262,0.00001125835,0.00007181689,0.00004432107,0.002483962],"genre_scores_gemma":[0.9966311,0.001026755,0.0007792553,0.00009526021,0.0000410662,0.00001755578,0.00007588638,0.00001430524,0.001318753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187849,"threshold_uncertainty_score":0.003973782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006678671155854466,"score_gpt":0.2349623820885965,"score_spread":0.2282837109327421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}