{"id":"W2055853647","doi":"10.1016/j.jsbmb.2015.01.004","title":"Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride","year":2015,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Consejo Nacional de Investigaciones Científicas y Técnicas; Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"Endocrinology; Internal medicine; Metabolite; Progestin; Medroxyprogesterone acetate; In vivo; Medroxyprogesterone; Cell growth; Progesterone receptor; Finasteride; Stimulation; Biology; Estrogen; Chemistry; Medicine; Breast cancer; Cancer; Biochemistry; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175419,0.0005587371,0.000364543,0.000630308,0.0003334485,0.0003011307,0.0002302653,0.0002353278,0.003868623],"category_scores_gemma":[0.0001929034,0.0003658653,0.0004954705,0.0003737782,0.0004457711,0.000202439,0.0003415944,0.0006991306,0.001196096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006145396,"about_ca_system_score_gemma":0.0007987946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004144584,"about_ca_topic_score_gemma":0.007650535,"domain_scores_codex":[0.9997838,0.00002573172,0.0000150423,0.00002587763,0.00007160418,0.00007793937],"domain_scores_gemma":[0.9998385,0.00001899194,0.00003885605,0.00002792809,0.00001291567,0.00006287844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006173205,0.00006511001,0.0003444835,0.00003654466,0.000008160026,0.0001951935,0.00001468218,0.000033043,0.9959074,0.0001430841,0.0001351315,0.00249967],"study_design_scores_gemma":[0.00004931081,0.0005535053,0.01392707,0.000007585721,0.00002033344,0.0008752016,0.00004434933,0.0002688268,0.9794973,0.0000934206,0.004655168,0.000007915157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826394,0.005258338,0.001972729,0.0005787705,0.0001484354,0.00006923575,0.00139986,0.0004987318,0.007434503],"genre_scores_gemma":[0.9827443,0.002685505,0.0007420321,0.00008997386,0.00002849326,0.00003777275,0.001246765,0.00003103539,0.01239407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004144584,"threshold_uncertainty_score":0.01294178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030690258610278,"score_gpt":0.2553705246590298,"score_spread":0.245063622072927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}