{"id":"W2055872765","doi":"10.1021/ja0351692","title":"Catalytic Enantioselective Conjugate Reduction of Lactones and Lactams","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":293,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Stryker; Bristol-Myers Squibb","keywords":"Chemistry; Enantioselective synthesis; Conjugate; Catalysis; Reduction (mathematics); Stereochemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002240065,0.0001000604,0.0003464598,0.00001494873,0.00004872694,0.000010699,0.0001664122,0.00004519378,0.00001808119],"category_scores_gemma":[0.0002761852,0.00006318742,0.0003973212,0.0003779099,0.0004182163,0.00005997987,0.00003327662,0.0002301567,4.943626e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009039407,"about_ca_system_score_gemma":0.00005973254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003472695,"about_ca_topic_score_gemma":1.245427e-7,"domain_scores_codex":[0.9991754,0.0000212343,0.0003150276,0.0001069772,0.0002473519,0.0001340367],"domain_scores_gemma":[0.9986539,0.0001328869,0.0008722676,0.0001530263,0.0001241059,0.0000638288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002944678,0.0000840753,0.003900292,0.00002576729,0.0002961479,3.778158e-7,0.0003404212,0.000001966796,0.9859661,0.00002828331,0.0008477835,0.008479345],"study_design_scores_gemma":[0.0002090223,0.0000174301,0.0006531894,0.00002786791,0.0001759314,0.0001107292,0.001920575,0.0000153049,0.9959374,0.0001717959,0.0006832464,0.00007749441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975641,0.0003080248,0.00003173755,0.000244079,0.0000336128,0.00001551062,0.000003595461,0.000004139219,0.001795167],"genre_scores_gemma":[0.9989298,0.0002639159,0.000553869,0.00004464857,0.00008044701,7.436136e-7,4.401921e-7,0.00001019009,0.0001159255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00997132,"threshold_uncertainty_score":0.2576708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007332479558810539,"score_gpt":0.2270287903997486,"score_spread":0.219696310840938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}