{"id":"W2055880533","doi":"10.1515/bc.2010.049","title":"Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor","year":2010,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canada Research Chairs","keywords":"Chemistry; Cathepsin O; Cathepsin A; Biochemistry; Cathepsin H; Cathepsin B; Cathepsin; Angiostatin; Molecular biology; Peptide; Angiogenesis; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002506405,0.0002304333,0.0002392488,0.00001627308,0.0001114433,0.00003006985,0.0001522685,0.0004740453,0.00001234201],"category_scores_gemma":[0.0003083721,0.000194259,0.00009101829,0.00005879604,0.0002761516,0.000007861534,0.00008833728,0.000146705,0.000001665984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009408564,"about_ca_system_score_gemma":0.0000536819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002776069,"about_ca_topic_score_gemma":0.000007168264,"domain_scores_codex":[0.9987499,0.00003012122,0.0003180297,0.0005659261,0.00008515524,0.0002508648],"domain_scores_gemma":[0.999262,0.0000406492,0.0001996716,0.0002476333,0.0001163319,0.0001336656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001557541,0.00009346871,0.0007503439,0.00004134011,0.00004284389,6.442297e-7,0.00004574399,2.210358e-7,0.9981928,0.00002579626,0.0002391514,0.0004118501],"study_design_scores_gemma":[0.0004853766,0.0002560668,0.0005104603,0.000008901866,0.00003393874,0.00002669899,0.00007489292,0.00003175614,0.9966841,0.0007315728,0.0009115889,0.0002446399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982984,0.0007634745,0.0001477957,0.00006682874,0.00004799336,0.0003150705,0.000213354,0.00001822908,0.0001288764],"genre_scores_gemma":[0.9983535,0.0001744074,0.0005156585,0.00005081961,0.0001754003,0.0001191031,0.0003272003,0.00001857194,0.0002653116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508736,"threshold_uncertainty_score":0.7921651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008205853355164121,"score_gpt":0.2290838401157215,"score_spread":0.2208779867605574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}