{"id":"W2055880533","doi":"10.1515/bc.2010.049","title":"Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor","year":2010,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canada Research Chairs","keywords":"Chemistry; Cathepsin O; Cathepsin A; Biochemistry; Cathepsin H; Cathepsin B; Cathepsin; Angiostatin; Molecular biology; Peptide; Angiogenesis; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863202,0.000285411,0.0002416264,0.0001516287,0.00008351292,0.0002424755,0.0001895377,0.0003090597,0.0004857055],"category_scores_gemma":[0.0002062138,0.0001232075,0.0003904806,0.0001971782,0.0001886123,0.0001779932,0.0001453013,0.0003184413,0.0001804923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002425333,"about_ca_system_score_gemma":0.0001583079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003555435,"about_ca_topic_score_gemma":0.0002838758,"domain_scores_codex":[0.9998248,0.00004491228,0.00001178186,0.00003536007,0.00003543005,0.00004771659],"domain_scores_gemma":[0.9998995,0.00002661707,0.00003360768,0.000007918409,0.00001292724,0.00001944911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007722389,0.00001036289,0.0001600292,0.00002781208,0.000005885008,0.00005250691,0.00001095371,0.00004621617,0.9986581,0.00004224951,0.000008449024,0.0009002384],"study_design_scores_gemma":[0.0000166689,0.0003218086,0.003100176,0.000005117603,0.00001399129,0.0006358989,0.00002036501,0.0007854135,0.9937416,0.00004644553,0.001306396,0.000006098228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891109,0.003044764,0.006546067,0.00005975785,0.00001285727,0.00002611979,0.000109219,0.00002571521,0.001064594],"genre_scores_gemma":[0.9922057,0.001014066,0.005288831,0.00004702911,0.000007439682,0.00002703304,0.0002475432,0.000009714267,0.001152594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004857055,"threshold_uncertainty_score":0.001759708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008205853355164121,"score_gpt":0.2290838401157215,"score_spread":0.2208779867605574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}