{"id":"W2055881574","doi":"10.1006/abbi.2000.1741","title":"Disruption of Cytoplasmic and Mitochondrial Folylpolyglutamate Synthetase Activity in Saccharomyces cerevisiae","year":2000,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"","keywords":"Auxotrophy; Biology; Biochemistry; Serine hydroxymethyltransferase; Saccharomyces cerevisiae; Gene; Mutant; Mitochondrion; Strain (injury); Serine; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002359166,0.0008972461,0.0004003692,0.0003539086,0.0003058562,0.0007436551,0.0006620968,0.0006448058,0.001175104],"category_scores_gemma":[0.0002322759,0.0004260653,0.0005553775,0.0003943692,0.0004934194,0.0003070643,0.0006456453,0.001093898,0.0006066767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007901713,"about_ca_system_score_gemma":0.0006356454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003899406,"about_ca_topic_score_gemma":0.004635323,"domain_scores_codex":[0.9997513,0.00003102894,0.00006159452,0.000048306,0.00006915741,0.00003865213],"domain_scores_gemma":[0.999649,0.00009359432,0.00009505642,0.0000565327,0.0000323657,0.00007332597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002444627,0.00004350277,0.0002127955,0.00004831126,0.00001823988,0.000212645,0.00003721574,0.0002767981,0.9971663,0.0005278579,0.0000373065,0.001174523],"study_design_scores_gemma":[0.00004952642,0.0001053378,0.001925175,0.00001061548,0.0000463252,0.0003499351,0.0001023715,0.001762846,0.9934098,0.0001131173,0.002109173,0.00001575204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906475,0.0008675655,0.005681181,0.0002373219,0.00008623028,0.00004685072,0.001049586,0.0002244635,0.001159276],"genre_scores_gemma":[0.9943808,0.0003725826,0.001793355,0.0000465518,0.00001098529,0.00002578185,0.000695421,0.00007661367,0.002597885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003899406,"threshold_uncertainty_score":0.007753372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005200958222296295,"score_gpt":0.2332861539009422,"score_spread":0.2280851956786459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}