{"id":"W2055909692","doi":"10.1021/mp400624v","title":"Modulation of Blood–Brain Barrier Permeability in Mice Using Synthetic E-Cadherin Peptide","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"NIH Blueprint for Neuroscience Research; National Institute of Neurological Disorders and Stroke","keywords":"Blood–brain barrier; Chemistry; Biophysics; Peptide; Permeability (electromagnetism); Efflux; Rhodamine; In vivo; P-glycoprotein; Biochemistry; Fluorescence; Biology; Central nervous system; Endocrinology; Membrane; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004052992,0.0008370146,0.0005576039,0.001014675,0.0002845621,0.000505209,0.0004751882,0.0008314051,0.001286322],"category_scores_gemma":[0.000200845,0.0003952384,0.0004380711,0.0003292139,0.0005715205,0.0008628766,0.0002437694,0.002070631,0.0003675407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004346533,"about_ca_system_score_gemma":0.0003524984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005490734,"about_ca_topic_score_gemma":0.0009237715,"domain_scores_codex":[0.9996164,0.00006233832,0.00004141735,0.0001035945,0.00007184388,0.0001043011],"domain_scores_gemma":[0.9996367,0.00006076937,0.0001223422,0.00004432646,0.00003581241,0.0001000311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003741838,0.0003205963,0.00008008657,0.00005105446,0.000007131031,0.00005238714,0.00002772169,0.00006716885,0.9973204,0.0001460103,0.00005056111,0.001502769],"study_design_scores_gemma":[0.00005819967,0.003413945,0.0009489693,0.000009713553,0.00002529985,0.0001678863,0.00002540047,0.0006461365,0.9929715,0.00007781948,0.001646217,0.000008807358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98702,0.002302206,0.007155265,0.0003231934,0.0001182705,0.0001933416,0.0007379008,0.0003192892,0.001830641],"genre_scores_gemma":[0.9715264,0.003895727,0.01373068,0.0002642177,0.00006365381,0.0004724694,0.001469919,0.0001004559,0.008476344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286322,"threshold_uncertainty_score":0.004303217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357576207968699,"score_gpt":0.3056894591111342,"score_spread":0.2821136970314472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}