{"id":"W2055927513","doi":"10.1016/j.ymgme.2010.02.005","title":"Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder","year":2010,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Children's Hospital","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Vitamin B12; Mutant; Biology; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000655518,0.0002448086,0.000270102,0.00007608923,0.0000635709,0.00003041292,0.0004004186,0.0001949609,0.00001608956],"category_scores_gemma":[0.0002346759,0.0001822104,0.000119476,0.000196701,0.0002943386,0.000004310053,0.0001618832,0.0002378964,0.000001766938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001366117,"about_ca_system_score_gemma":0.00008778378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009683021,"about_ca_topic_score_gemma":0.0001745709,"domain_scores_codex":[0.9983941,0.0002537654,0.0003336804,0.0004474569,0.0002483714,0.0003226141],"domain_scores_gemma":[0.9989024,0.00001920422,0.0001142001,0.0007806527,0.0001000696,0.00008341503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006212309,0.0001527513,0.001450442,0.00001657841,0.00002555669,0.000006416695,0.0002161444,0.00001494637,0.9878522,0.003263748,0.00002047374,0.006918631],"study_design_scores_gemma":[0.001963502,0.0001337366,0.177683,0.000008698847,0.00009090109,0.00002517239,0.0004319171,0.00008519927,0.7373168,0.004906808,0.07687771,0.000476481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910764,0.006618794,0.0007025205,0.0002459203,0.0001775421,0.0006132604,0.000042378,0.000005025393,0.0005181228],"genre_scores_gemma":[0.9976017,0.0003792154,0.001402318,0.0003709184,0.00006924729,0.00008343634,0.0000219485,0.00002794261,0.00004319782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2505353,"threshold_uncertainty_score":0.7430326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003051753186495228,"score_gpt":0.2206690712558226,"score_spread":0.2176173180693274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}