{"id":"W2055939327","doi":"10.1038/srep09344","title":"Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; In vivo; Phenotype; Biochemistry; Cell biology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002527064,0.0003928495,0.0003107373,0.0001513402,0.0001063171,0.0001533068,0.0002068258,0.0002739308,0.00153924],"category_scores_gemma":[0.0001509376,0.0001187015,0.0002518047,0.0001160454,0.0001536312,0.0002030716,0.0001109927,0.000696859,0.0005526245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000190096,"about_ca_system_score_gemma":0.0001708894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002048264,"about_ca_topic_score_gemma":0.0003598042,"domain_scores_codex":[0.9999429,0.00001049663,0.000005514175,0.00001257454,0.00001667205,0.00001183578],"domain_scores_gemma":[0.999934,0.00001460955,0.00001650088,0.000005824344,0.00001384362,0.00001528029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001598188,0.00006466339,0.00004869272,0.00004695415,0.000008024455,0.00003284913,0.000008140412,0.0001461767,0.9964399,0.00008323517,0.00007560579,0.00288598],"study_design_scores_gemma":[0.00002829411,0.0008941574,0.0008510984,0.000005382216,0.00001685544,0.0001485446,0.000006277644,0.0005970904,0.9949942,0.00004104687,0.002411514,0.0000054995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631993,0.00989123,0.01910633,0.0004166005,0.00007908814,0.0002446085,0.001792993,0.0001868826,0.005082966],"genre_scores_gemma":[0.9671058,0.00782622,0.01737995,0.0004046308,0.0000497755,0.0002315841,0.0024901,0.00003518058,0.004476796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153924,"threshold_uncertainty_score":0.005149245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801978423264054,"score_gpt":0.2653207138840368,"score_spread":0.2473009296513962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}