{"id":"W2055939327","doi":"10.1038/srep09344","title":"Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; In vivo; Phenotype; Biochemistry; Cell biology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007868956,0.0001355453,0.0001860581,0.00004539302,0.000140078,0.00008575783,0.0001322431,0.0001169899,0.00004182577],"category_scores_gemma":[0.0003193285,0.00009167018,0.0001307851,0.0002698823,0.0004388414,0.000006476799,0.00008671269,0.00007869338,0.000003378532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001232607,"about_ca_system_score_gemma":0.000123466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007418046,"about_ca_topic_score_gemma":0.000001574356,"domain_scores_codex":[0.9985375,0.0000650442,0.0003892382,0.0005177512,0.0002803451,0.0002101502],"domain_scores_gemma":[0.9990218,0.00003237079,0.0002341351,0.0004002187,0.0001617381,0.0001497394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001645821,0.00008580621,0.004892683,0.000007269885,0.00003933466,0.000007461288,0.00002672912,0.00001037267,0.9911541,0.000013787,0.002177474,0.001568461],"study_design_scores_gemma":[0.0001641823,0.00003368032,0.0006039903,0.00001513668,0.00008857847,0.00002860429,0.000048149,0.0001914873,0.9788253,0.000223474,0.01965062,0.0001267702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972594,0.001039022,0.0003085772,0.0005000975,0.0004182803,0.0001267873,0.00000829357,0.00001216277,0.0003274106],"genre_scores_gemma":[0.9991162,0.00001423706,0.0002382398,0.0001112788,0.0001092908,0.0000169635,0.0001583227,0.00001054054,0.0002249116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01747314,"threshold_uncertainty_score":0.3738201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801978423264054,"score_gpt":0.2653207138840368,"score_spread":0.2473009296513962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}