{"id":"W2055979884","doi":"10.1038/sj.cgt.7700566","title":"A “combination oligonucleotide” antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance","year":2003,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Occupational Cancer Research Centre","funders":"","keywords":"Thymidylate synthase; Messenger RNA; Cell growth; Antisense therapy; Biology; Downregulation and upregulation; Raltitrexed; Molecular biology; Oligonucleotide; Antisense RNA; Cell; Cancer research; Biochemistry; DNA; Chemotherapy; Gene; Fluorouracil; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589691,0.0001960222,0.0001543862,0.00004562897,0.0001048893,0.00005546465,0.0001040313,0.00007071175,0.00002387634],"category_scores_gemma":[0.00004079839,0.0001790843,0.00004264796,0.0001232076,0.000112171,0.000005806798,0.00004923826,0.00008254364,0.000002224359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001334651,"about_ca_system_score_gemma":0.0001081619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005733874,"about_ca_topic_score_gemma":0.00002924998,"domain_scores_codex":[0.9988019,0.0001061565,0.0001480983,0.0004984192,0.0001316233,0.0003138218],"domain_scores_gemma":[0.9992564,0.00001011472,0.00004642104,0.0002567626,0.00008817529,0.0003420779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003460516,0.00006354137,0.0002118385,0.00003471498,0.00002867684,0.0000167883,0.00004251111,0.000003782988,0.9963681,0.0001889526,0.0006621279,0.002032891],"study_design_scores_gemma":[0.001257628,0.000161971,0.0006784056,0.00001851236,0.000008631982,0.00001243721,0.00001964606,0.000005659803,0.9904394,0.0004069001,0.006746563,0.0002442959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798523,0.01864929,0.0001337247,0.000398683,0.00003848819,0.0003369881,0.00002591379,0.00001248868,0.00055213],"genre_scores_gemma":[0.9899002,0.007749966,0.0005282635,0.0008438283,0.00004584001,0.00005874755,0.00001985621,0.00003351425,0.0008197241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01089932,"threshold_uncertainty_score":0.7302846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009110159869877382,"score_gpt":0.2558961688268623,"score_spread":0.2467860089569849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}