{"id":"W2055979884","doi":"10.1038/sj.cgt.7700566","title":"A “combination oligonucleotide” antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance","year":2003,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Occupational Cancer Research Centre","funders":"","keywords":"Thymidylate synthase; Messenger RNA; Cell growth; Antisense therapy; Biology; Downregulation and upregulation; Raltitrexed; Molecular biology; Oligonucleotide; Antisense RNA; Cell; Cancer research; Biochemistry; DNA; Chemotherapy; Gene; Fluorouracil; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000249669,0.0005892265,0.0005203955,0.0004483829,0.0002509972,0.0003283763,0.000352684,0.0004535907,0.001916184],"category_scores_gemma":[0.0001443006,0.0003045276,0.0003808435,0.0002552129,0.0001904498,0.000337375,0.0002668206,0.0008284351,0.0005274028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003775141,"about_ca_system_score_gemma":0.0004074731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006148674,"about_ca_topic_score_gemma":0.001417507,"domain_scores_codex":[0.9997613,0.00003758344,0.00002199053,0.00006429599,0.00008005819,0.00003474458],"domain_scores_gemma":[0.9999167,0.00001313782,0.0000169823,0.00001576263,0.00001665188,0.00002081271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00016108,0.00008123063,0.0001053937,0.00003871209,0.00001470711,0.00004839718,0.000007271082,0.0002032817,0.9922639,0.000466237,0.000305956,0.006303824],"study_design_scores_gemma":[0.00009442072,0.0007919401,0.0006120874,0.000003168861,0.00005999554,0.0005600314,0.000004779347,0.001670565,0.9897455,0.00008629288,0.006360193,0.00001111773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9130206,0.004982938,0.06252455,0.0009816685,0.0007993649,0.0006077662,0.0008819212,0.001187808,0.01501337],"genre_scores_gemma":[0.9422872,0.001980649,0.04367306,0.0003637234,0.0001136548,0.0003639554,0.0006845645,0.0001276102,0.01040555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916184,"threshold_uncertainty_score":0.006410241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009110159869877382,"score_gpt":0.2558961688268623,"score_spread":0.2467860089569849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}