{"id":"W2055986128","doi":"10.1016/j.ccr.2014.07.028","title":"Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer","year":2014,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1246,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institutes of Health; National Cancer Institute; Princess Margaret Cancer Foundation","keywords":"DNA methylation; Methylation; Biology; Gene; Promoter; Gene expression; Epigenetics; Carcinogenesis; Regulation of gene expression; Epigenetics of physical exercise; RNA-Directed DNA Methylation; Demethylation; Cancer research; Genetics; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002271311,0.0002204916,0.0002499188,0.0003170968,0.0002523476,0.0003911244,0.0002047524,0.00037427,0.003458136],"category_scores_gemma":[0.0002011079,0.0001584101,0.000173519,0.0003088824,0.0003148081,0.0002732539,0.0002595957,0.0006883266,0.0005064942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003398936,"about_ca_system_score_gemma":0.0002633553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005255853,"about_ca_topic_score_gemma":0.001088108,"domain_scores_codex":[0.999905,0.0000224823,0.000004448268,0.00001752201,0.00002959972,0.00002103636],"domain_scores_gemma":[0.9999504,0.00001187421,0.00001330367,0.00000917931,0.000007208476,0.000007983189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005036651,0.0001217925,0.003213296,0.0002479565,0.00006966614,0.0003238682,0.0001093833,0.0009217887,0.8946617,0.007406137,0.002172937,0.0902478],"study_design_scores_gemma":[0.00005745699,0.0008957238,0.0135607,0.00003245617,0.0001058129,0.001221466,0.0001206304,0.001449792,0.9274713,0.003234713,0.05183519,0.00001471726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8064721,0.0938677,0.02864195,0.008381699,0.0009008422,0.0001856715,0.001290791,0.0009389521,0.05932034],"genre_scores_gemma":[0.9767731,0.01119235,0.001506883,0.0002854112,0.00007058449,0.00002971136,0.0001800433,0.00003786776,0.009924157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003458136,"threshold_uncertainty_score":0.01156867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302609287177919,"score_gpt":0.278225427895976,"score_spread":0.2651993350241968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}