{"id":"W2056030232","doi":"10.1074/jbc.m106737200","title":"Hepatic Very Low Density Lipoprotein-ApoB Overproduction Is Associated with Attenuated Hepatic Insulin Signaling and Overexpression of Protein-tyrosine Phosphatase 1B in a Fructose-fed Hamster Model of Insulin Resistance","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Hospital for Sick Children; Heart and Stroke Foundation of Canada","keywords":"Insulin resistance; Internal medicine; Overproduction; Endocrinology; Hamster; Protein tyrosine phosphatase; Insulin; Apolipoprotein B; Fructose; Insulin receptor; Chemistry; Phosphatase; Biology; Biochemistry; Tyrosine; Medicine; Cholesterol; Phosphorylation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004351186,0.0002405884,0.0008505445,0.00006833248,0.0000382291,0.00001204891,0.0001069329,0.0003087228,0.0000979604],"category_scores_gemma":[0.001487108,0.0001625377,0.0001306133,0.000296446,0.0002037466,0.0001397758,0.00004731006,0.000496182,5.545155e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000832876,"about_ca_system_score_gemma":0.00009447522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002419635,"about_ca_topic_score_gemma":0.000002208599,"domain_scores_codex":[0.9980087,0.00008773023,0.0009146862,0.0002990817,0.0004597555,0.0002300845],"domain_scores_gemma":[0.9980091,0.00007536497,0.00103411,0.0002394779,0.0004370994,0.0002048896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006739327,0.001759363,0.01237287,0.0009179014,0.0001151012,0.00009462156,0.0001948287,0.00008631837,0.9770008,0.000001372347,0.00007504018,0.0006424398],"study_design_scores_gemma":[0.006423248,0.0004714466,0.02125901,0.004517842,0.0001711084,0.00002667802,0.00007839635,0.003705768,0.9628912,0.000238772,0.000004843113,0.0002117444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932278,0.006118714,0.00004469435,0.000142938,0.0000170825,0.0003219082,0.00007196105,0.00001194753,0.00004300289],"genre_scores_gemma":[0.998302,0.0005132359,0.0008378659,0.0001230311,0.00007923284,0.000006704259,0.00002591567,0.00001487473,0.00009718206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01410968,"threshold_uncertainty_score":0.6628094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201083574451702,"score_gpt":0.2268096523529877,"score_spread":0.2067012949078175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}