{"id":"W2056030232","doi":"10.1074/jbc.m106737200","title":"Hepatic Very Low Density Lipoprotein-ApoB Overproduction Is Associated with Attenuated Hepatic Insulin Signaling and Overexpression of Protein-tyrosine Phosphatase 1B in a Fructose-fed Hamster Model of Insulin Resistance","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Hospital for Sick Children; Heart and Stroke Foundation of Canada","keywords":"Insulin resistance; Internal medicine; Overproduction; Endocrinology; Hamster; Protein tyrosine phosphatase; Insulin; Apolipoprotein B; Fructose; Insulin receptor; Chemistry; Phosphatase; Biology; Biochemistry; Tyrosine; Medicine; Cholesterol; Phosphorylation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210375,0.0004304937,0.0005328265,0.0004445272,0.0002237485,0.0003292318,0.0001928177,0.0003884188,0.001475224],"category_scores_gemma":[0.0001039651,0.0002576559,0.0003500207,0.0002616108,0.0004023604,0.0002446794,0.0002673464,0.0007627571,0.0002692824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003195989,"about_ca_system_score_gemma":0.0001773974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005337943,"about_ca_topic_score_gemma":0.0005886236,"domain_scores_codex":[0.9998364,0.00002517396,0.00002143166,0.00004368036,0.00003357487,0.00003961705],"domain_scores_gemma":[0.9998519,0.00001223711,0.00003711399,0.00002281375,0.000009706041,0.00006620413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012894,0.000138351,0.0006954518,0.00004457243,0.000013837,0.0001758661,0.00002002951,0.00004279263,0.9969724,0.00007234958,0.00003150637,0.0007798829],"study_design_scores_gemma":[0.0002403574,0.004214379,0.03851823,0.00001393604,0.00009529624,0.001688603,0.0001015134,0.001767615,0.9511648,0.0001560725,0.002020298,0.00001883936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976452,0.0005771746,0.0009728631,0.00007147658,0.00003064796,0.00003060129,0.0001910187,0.00004690222,0.0004340771],"genre_scores_gemma":[0.9962263,0.0004596695,0.001274668,0.00004796663,0.00001476646,0.00005713065,0.0003306322,0.00001904576,0.001569858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475224,"threshold_uncertainty_score":0.004935086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201083574451702,"score_gpt":0.2268096523529877,"score_spread":0.2067012949078175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}