{"id":"W2056031636","doi":"10.1128/jvi.01416-09","title":"Coxsackievirus B3 Infection Activates the Unfolded Protein Response and Induces Apoptosis through Downregulation of p58 <sup>IPK</sup> and Activation of CHOP and SREBP1","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Heart and Stroke Foundation of Canada","keywords":"Unfolded protein response; XBP1; Protein kinase R; Biology; EIF-2 kinase; Downregulation and upregulation; Endoplasmic reticulum; ATF6; ATF4; Cell biology; Caspase 12; Activating transcription factor; Molecular biology; Protein kinase A; Kinase; Apoptosis; Programmed cell death; Caspase; RNA splicing; RNA; Cyclin-dependent kinase 2; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178257,0.0003274356,0.0001810291,0.0002172302,0.0001699379,0.0002438947,0.00008646286,0.0002184234,0.001132708],"category_scores_gemma":[0.00006365742,0.000148346,0.0003176426,0.0001624243,0.0001781967,0.0001270615,0.0001819348,0.0005319077,0.0003561715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660826,"about_ca_system_score_gemma":0.0001528319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006211403,"about_ca_topic_score_gemma":0.0008113458,"domain_scores_codex":[0.9998716,0.00001703607,0.00001464023,0.00002543388,0.00003409358,0.00003720953],"domain_scores_gemma":[0.999939,0.000009241076,0.00001790239,0.000006886036,0.00000764072,0.00001941926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001014093,0.00001166749,0.0002165954,0.00002127977,0.00000328133,0.00004031833,0.000007937915,0.000009836919,0.9992779,0.00002105471,0.00001303168,0.0002756985],"study_design_scores_gemma":[0.00002639675,0.000307467,0.03037847,0.00000956224,0.00001346378,0.0004723403,0.00005572334,0.0005874598,0.9664378,0.0000492456,0.001656227,0.00000601438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959632,0.001597124,0.001068877,0.00006627278,0.00002452074,0.00001466794,0.0003920072,0.0000301018,0.0008432845],"genre_scores_gemma":[0.9935463,0.001216911,0.001666377,0.00007634131,0.0000150856,0.00004851309,0.001327011,0.0000207313,0.002082745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132708,"threshold_uncertainty_score":0.003789246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007358526067869985,"score_gpt":0.2495488861650926,"score_spread":0.2421903600972226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}