{"id":"W2056042156","doi":"10.1007/s10495-007-0165-6","title":"Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol","year":2007,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"XIAP; Protein kinase B; Cisplatin; Cancer research; HeLa; Apoptosis; PI3K/AKT/mTOR pathway; Chemistry; Inhibitor of apoptosis; Cancer cell; Biology; Cancer; Cell; Internal medicine; Medicine; Programmed cell death; Chemotherapy; Biochemistry; Caspase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487975,0.0001464031,0.0001801142,0.0003412978,0.0002155407,0.0003337996,0.0001347443,0.0001978,0.00178577],"category_scores_gemma":[0.0002752558,0.000236364,0.000161911,0.000279905,0.0002419801,0.0002738733,0.0001882986,0.0003703453,0.0002637063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004436851,"about_ca_system_score_gemma":0.0002700532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001369954,"about_ca_topic_score_gemma":0.001494501,"domain_scores_codex":[0.9998972,0.00002706645,0.000009976829,0.00001030156,0.00002145513,0.00003387998],"domain_scores_gemma":[0.9999141,0.00003096519,0.00001306969,0.00001287523,0.00001152832,0.00001747636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001593776,0.00008950082,0.004249309,0.0000793235,0.00002353601,0.0001857893,0.0001180349,0.0004374613,0.9878047,0.000783429,0.0002532948,0.004381808],"study_design_scores_gemma":[0.00009062519,0.0005215497,0.07416724,0.00001181247,0.00004269248,0.0006356967,0.0002202825,0.002725978,0.9177395,0.0002684063,0.003566471,0.000009798363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955387,0.002045864,0.000434601,0.000110149,0.00001726328,0.00001378555,0.0002328472,0.00002178589,0.001585095],"genre_scores_gemma":[0.9974619,0.0008006022,0.00017508,0.00002414645,0.000003530772,0.00001636856,0.0002017145,0.000002726652,0.00131378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178577,"threshold_uncertainty_score":0.005973935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008455288410101387,"score_gpt":0.2726276874059689,"score_spread":0.2641723989958675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}