{"id":"W2056056608","doi":"10.1038/cgt.2009.80","title":"Human neural stem cells transduced with IFN-β and cytosine deaminase genes intensify bystander effect in experimental glioma","year":2009,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"National Science Council","keywords":"Cytosine deaminase; Bystander effect; Glioma; Cancer research; Suicide gene; Prodrug; Neural stem cell; Genetic enhancement; Biology; Stem cell; Pharmacology; Gene; Immunology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003584223,0.0005080282,0.000536073,0.0006613019,0.0001876072,0.000311263,0.0002091525,0.0003674095,0.001596902],"category_scores_gemma":[0.0001408525,0.0002084508,0.00040062,0.0003353498,0.0004654459,0.0003439219,0.000223069,0.0008054399,0.0002768174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002629052,"about_ca_system_score_gemma":0.0002769193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097101,"about_ca_topic_score_gemma":0.0007204624,"domain_scores_codex":[0.9997984,0.00005336214,0.00001737803,0.00002579583,0.00004123231,0.00006385717],"domain_scores_gemma":[0.9998893,0.00003992154,0.00001610665,0.00002330558,0.000008583125,0.00002285208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007621074,0.000165373,0.0001713969,0.00004194924,0.00001194613,0.00008297764,0.00005593283,0.00008631486,0.9964482,0.0002823313,0.0000572093,0.00183421],"study_design_scores_gemma":[0.00006079419,0.0006117513,0.0007985544,0.000002242879,0.00002984075,0.0001251503,0.00002351628,0.0004288103,0.9972222,0.00006515799,0.0006299671,0.000002079166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968169,0.0009407905,0.001017924,0.00005203494,0.00003439273,0.00003505843,0.00008628227,0.00006417301,0.0009525304],"genre_scores_gemma":[0.997548,0.0005138986,0.000585991,0.00002155002,0.0000125131,0.00002813123,0.0001153533,0.00001611549,0.001158348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596902,"threshold_uncertainty_score":0.005342126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03365276231240223,"score_gpt":0.338311079625554,"score_spread":0.3046583173131517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}