{"id":"W2056068952","doi":"10.1002/art.30625","title":"R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts","year":2011,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Osteoblast; Chemistry; Internal medicine; Endocrinology; Bone remodeling; Cell biology; Signal transduction; Biology; In vitro; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004886197,0.0003403223,0.0004261914,0.0002373947,0.0000963295,0.00004984459,0.0003128397,0.0003015418,0.0004715327],"category_scores_gemma":[0.00007891173,0.000390344,0.0001146353,0.0002800759,0.0001222801,0.00003521751,0.0001471759,0.0002360847,0.00006610866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005556558,"about_ca_system_score_gemma":0.000111116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003925355,"about_ca_topic_score_gemma":0.004940048,"domain_scores_codex":[0.9976774,0.00014706,0.0006177413,0.0006656387,0.0002560937,0.0006359991],"domain_scores_gemma":[0.9992034,0.00003027152,0.0002311106,0.0003381462,0.00006324883,0.0001338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164162,0.000331633,0.187579,0.0001012781,0.0001447111,0.0006316485,0.007726078,0.0002400394,0.3396048,0.0003199001,0.003157751,0.4589991],"study_design_scores_gemma":[0.0178501,0.0009202847,0.1821183,0.006587952,0.00001982796,0.0002710562,0.002080611,0.00006691695,0.7802548,0.00295263,0.004651525,0.002226074],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900187,0.007139376,0.000137573,0.00007919109,0.0004312439,0.0003957538,0.00002168755,0.00003946031,0.001736982],"genre_scores_gemma":[0.9922852,0.004369105,0.002234492,0.0001875181,0.0000536456,0.0001522053,0.0001020977,0.00006261963,0.0005531542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.456773,"threshold_uncertainty_score":0.9998549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193975178195066,"score_gpt":0.2174807527202711,"score_spread":0.1955410009383204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}