{"id":"W2056075767","doi":"10.1021/bi051180y","title":"Roles of Dimerization Domain Residues in Binding and Catalysis by Aminoacylase-1","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Chemistry; Stereochemistry; Active site; Protein subunit; Binding site; Dimer; Mutagenesis; Asparagine; Site-directed mutagenesis; Enzyme; Complementation; Biochemistry; Mutation; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006592053,0.00006362922,0.0001450818,0.00006866187,0.00001690751,0.000005233049,0.00002231238,0.00005961693,0.00006155523],"category_scores_gemma":[0.00003966003,0.00006089235,0.00003577265,0.0001792357,0.00005057193,0.00002938937,0.00001376691,0.00004689218,0.000003092254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002855276,"about_ca_system_score_gemma":0.00001694301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001926927,"about_ca_topic_score_gemma":0.00001360821,"domain_scores_codex":[0.9995072,0.000007836973,0.0001701459,0.0001350068,0.0001020616,0.00007771471],"domain_scores_gemma":[0.9997527,0.00001212939,0.00005742608,0.0001065271,0.00001928881,0.00005193516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001443943,0.0000693969,0.01552309,0.00005417029,0.00001758656,0.00000260146,0.00007934742,9.747772e-7,0.9823465,0.000002643871,0.0009311108,0.0009581969],"study_design_scores_gemma":[0.0004499176,0.000009053862,0.001308076,0.0001757296,0.00002951339,0.00000559197,0.0003384337,0.00009883194,0.9972842,0.000004354018,0.0002375141,0.00005872171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998071,0.000355705,0.00003562487,0.0006637828,0.000001131913,0.00002598927,0.00002253454,0.00001238744,0.0008118072],"genre_scores_gemma":[0.9983149,0.00005342794,0.0004401957,0.00007685659,0.00003751764,0.000003015795,0.0003008779,0.000005254367,0.0007679938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01493782,"threshold_uncertainty_score":0.2483118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004766575020003579,"score_gpt":0.2359964670252858,"score_spread":0.2312298920052822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}