{"id":"W2056075767","doi":"10.1021/bi051180y","title":"Roles of Dimerization Domain Residues in Binding and Catalysis by Aminoacylase-1","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Chemistry; Stereochemistry; Active site; Protein subunit; Binding site; Dimer; Mutagenesis; Asparagine; Site-directed mutagenesis; Enzyme; Complementation; Biochemistry; Mutation; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002759295,0.0001969567,0.0002139084,0.00007380569,0.0003391335,0.0003338926,0.0002008748,0.0003174661,0.0006313776],"category_scores_gemma":[0.0002271939,0.0001214355,0.0001428546,0.00007955556,0.0002256949,0.0003490731,0.0002302824,0.0003419154,0.0003705001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002984924,"about_ca_system_score_gemma":0.0002008375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003019644,"about_ca_topic_score_gemma":0.0003347397,"domain_scores_codex":[0.9998475,0.00004339559,0.000009375777,0.00004106203,0.00002915596,0.00002931883],"domain_scores_gemma":[0.9998806,0.00002619487,0.00002917648,0.000009117111,0.000009470284,0.00004553994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005327624,0.00006138189,0.001730013,0.00003819009,0.000004554948,0.0001516423,0.00007925768,0.0005889586,0.9926695,0.0005497907,0.00007654545,0.003517528],"study_design_scores_gemma":[0.00008400533,0.0002928997,0.0171776,0.00001280745,0.00001776912,0.001155115,0.0001872946,0.01745756,0.9600046,0.0009628426,0.002622584,0.00002511261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965173,0.001043634,0.001814934,0.00007013768,0.000007826942,0.000005040968,0.00003251834,0.00002512619,0.0004833967],"genre_scores_gemma":[0.998503,0.0001753045,0.0009180397,0.0000200396,0.000003144217,0.00000224169,0.00005659037,0.000003513989,0.0003182309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006313776,"threshold_uncertainty_score":0.002165675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004766575020003579,"score_gpt":0.2359964670252858,"score_spread":0.2312298920052822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}