{"id":"W2056111782","doi":"10.1038/cr.2012.167","title":"β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology","year":2012,"lang":"en","type":"article","venue":"Cell Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; Chinese Academy of Sciences; University of Alberta; KU Leuven; University of Pennsylvania","keywords":"Biology; Genetically modified mouse; Pathogenesis; Amyloid precursor protein secretase; Transgene; BACE1-AS; Presenilin; Senile plaques; Phenotype; Gamma secretase; Amyloid (mycology); Amyloid precursor protein; Alzheimer's disease; Cell biology; Disease; Pathology; Neuroscience; Immunology; Gene; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155743,0.0001983855,0.0003219558,0.0003168469,0.0003245381,0.00005642629,0.0001409328,0.0001366623,0.0006097102],"category_scores_gemma":[0.0002468137,0.0001570294,0.00007647278,0.0003685364,0.0005712521,0.0001623029,0.0002747425,0.0004799277,0.0007142939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009015958,"about_ca_system_score_gemma":0.0001793837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001218137,"about_ca_topic_score_gemma":0.000004903227,"domain_scores_codex":[0.9968132,0.0003968498,0.000213562,0.0004091346,0.0008322191,0.001335029],"domain_scores_gemma":[0.9972818,0.0004833104,0.00003393162,0.0005360986,0.0003067392,0.001358086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001549929,0.003603917,0.8297805,0.0007428794,0.002015177,0.002410802,0.0007754705,0.000002741457,0.1184823,0.0009362022,0.02102227,0.01867789],"study_design_scores_gemma":[0.004193968,0.00116281,0.9392494,0.00009650258,0.000239968,0.0003367768,0.000467633,0.00136289,0.04539725,0.001066855,0.006079726,0.0003462373],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669333,0.02148766,0.000005880278,0.0005803564,0.00004201798,0.0006700668,0.0000289809,0.00006012692,0.01019167],"genre_scores_gemma":[0.9973541,0.0007066652,0.0005525628,0.0000679751,0.0002214964,0.00007279407,0.0001882395,0.00004338691,0.0007927913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1094689,"threshold_uncertainty_score":0.9181041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1248060056921597,"score_gpt":0.4002697372455256,"score_spread":0.2754637315533659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}