{"id":"W2056119329","doi":"10.1016/j.expneurol.2004.01.006","title":"Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease","year":2004,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Quinolinic acid; Neuroprotection; Oxidative phosphorylation; Chemistry; Striatum; Lipid peroxidation; Pharmacology; Neurodegeneration; Neurotoxicity; Oxidative stress; Biochemistry; Biology; Internal medicine; Endocrinology; Medicine; Dopamine; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005869793,0.0002184043,0.0003574644,0.0001694875,0.00004110403,0.000005303968,0.0001795085,0.00008322723,0.00001574723],"category_scores_gemma":[0.0003395445,0.0002226304,0.00008406246,0.0003586218,0.0003155948,0.0001440633,0.0001027097,0.0001718529,9.737973e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003093778,"about_ca_system_score_gemma":0.0001329791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005614232,"about_ca_topic_score_gemma":0.00000598206,"domain_scores_codex":[0.9980409,0.0002686626,0.0005030814,0.0005474953,0.0003671393,0.0002727908],"domain_scores_gemma":[0.9989913,0.00008585157,0.0005006822,0.0002683226,0.00005834673,0.0000954945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001101222,0.001562711,0.001298464,0.00001443418,0.000004686704,0.000004157716,0.0004121306,0.006293309,0.9891672,0.0001272862,0.000006950175,0.000007476567],"study_design_scores_gemma":[0.002526852,0.001358875,0.003486481,0.00002762882,0.000008588421,5.159658e-7,0.00001911947,0.001832412,0.9903275,0.0002722942,2.232769e-7,0.0001394663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988722,0.00000793645,0.00007119881,0.0002679502,0.00005628121,0.0005415679,0.0001264252,0.00002418972,0.0000322455],"genre_scores_gemma":[0.9988986,0.000003179684,0.00002196154,0.0009620084,0.00001148259,0.00005686342,0.0000113216,0.00003107127,0.000003492145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004460898,"threshold_uncertainty_score":0.9078605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02955841306900465,"score_gpt":0.2756668204399808,"score_spread":0.2461084073709761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}