{"id":"W2056165940","doi":"10.1074/jbc.m802737200","title":"Mechanism of Influenza A Virus NS1 Protein Interaction with the p85β, but Not the p85α, Subunit of Phosphatidylinositol 3-Kinase (PI3K) and Up-regulation of PI3K Activity","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"PI3K/AKT/mTOR pathway; Phosphatidylinositol; Protein subunit; Mutant; P110α; Protein kinase B; Immunoprecipitation; Phosphoinositide 3-kinase; Cell biology; Phosphorylation; Influenza A virus; Chemistry; Biology; Kinase; Virus; Molecular biology; Signal transduction; Biochemistry; Virology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158205,0.0004668098,0.0001746677,0.0001514899,0.0003057165,0.0002679589,0.0003762693,0.0003403401,0.001032424],"category_scores_gemma":[0.00006345807,0.0002264776,0.0004255782,0.00007736956,0.000200742,0.0002862708,0.0002101983,0.000351097,0.0006936586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005093475,"about_ca_system_score_gemma":0.000235357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363653,"about_ca_topic_score_gemma":0.000754516,"domain_scores_codex":[0.9999059,0.00001571057,0.000005910484,0.00001876489,0.0000286857,0.00002492045],"domain_scores_gemma":[0.9999646,0.000005391711,0.00001110547,0.000004429884,0.000005614662,0.0000088848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001918776,0.00006835227,0.0009107728,0.00009641146,0.00001909414,0.0002143266,0.0000257202,0.0002392199,0.9959816,0.0007577598,0.0001138383,0.001381071],"study_design_scores_gemma":[0.00006622996,0.0002865131,0.02222407,0.00002435684,0.0000428207,0.001140786,0.00009339193,0.01255799,0.9597355,0.0005765665,0.003233248,0.00001855719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902621,0.003239338,0.003473759,0.0001677989,0.00003553514,0.00005088717,0.0002156184,0.00006175096,0.002493269],"genre_scores_gemma":[0.9959222,0.001129326,0.001096117,0.00004568699,0.000008984822,0.00003347183,0.0002996156,0.000005689361,0.001458927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001363653,"threshold_uncertainty_score":0.003695607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08785903280179128,"score_gpt":0.3351248424068126,"score_spread":0.2472658096050213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}