{"id":"W2056165940","doi":"10.1074/jbc.m802737200","title":"Mechanism of Influenza A Virus NS1 Protein Interaction with the p85β, but Not the p85α, Subunit of Phosphatidylinositol 3-Kinase (PI3K) and Up-regulation of PI3K Activity","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"PI3K/AKT/mTOR pathway; Phosphatidylinositol; Protein subunit; Mutant; P110α; Protein kinase B; Immunoprecipitation; Phosphoinositide 3-kinase; Cell biology; Phosphorylation; Influenza A virus; Chemistry; Biology; Kinase; Virus; Molecular biology; Signal transduction; Biochemistry; Virology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005909695,0.0001529708,0.000482371,0.00003808571,0.0001088888,0.000005552929,0.000163487,0.0001389185,0.00006819311],"category_scores_gemma":[0.0007497659,0.00006769356,0.0001269314,0.0001680947,0.0006705149,0.00009310302,0.00009694826,0.0005320937,4.660889e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005712571,"about_ca_system_score_gemma":0.0001245409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006650967,"about_ca_topic_score_gemma":0.000002077436,"domain_scores_codex":[0.9986073,0.0001101104,0.0005007254,0.0001272821,0.0004912968,0.0001633122],"domain_scores_gemma":[0.9978067,0.0003392457,0.0009347052,0.0002109119,0.0006364923,0.00007192956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005397177,0.0002157171,0.002462756,0.0001837409,0.0001958569,0.00001378561,0.0003396093,0.00001460555,0.9900956,0.00002349871,0.0000355233,0.001022188],"study_design_scores_gemma":[0.001316226,0.0009357105,0.04063806,0.0002178,0.00006488258,0.0001835965,0.000437842,0.00006988258,0.9558135,0.0000607076,0.0001971851,0.00006458157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985864,0.0003650171,0.0001032435,0.0004252007,0.00001829964,0.0003133598,0.00001821371,0.000004936683,0.0001653459],"genre_scores_gemma":[0.9993865,0.0002019925,0.0001502674,0.00008106685,0.00008836672,0.00001062184,0.00000108775,0.000006756342,0.00007330077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0381753,"threshold_uncertainty_score":0.2760463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08785903280179128,"score_gpt":0.3351248424068126,"score_spread":0.2472658096050213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}