{"id":"W2056169693","doi":"10.1096/fj.10-158972","title":"The active Zot domain (aa 288–293) increases ZO‐1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO‐1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation","year":2010,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Phosphorylation; Occludin; Cell biology; Serine; Myosin light-chain kinase; Tight junction; Biology; Myosin; Chemistry; Biochemistry; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008177228,0.0002864605,0.0001979593,0.0001671453,0.0001163384,0.0002426302,0.0001553081,0.0002979028,0.00213677],"category_scores_gemma":[0.00009833065,0.0001784281,0.0002769645,0.0001344717,0.0002649985,0.0001730649,0.0001780703,0.0007008377,0.0003370079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966028,"about_ca_system_score_gemma":0.0001618128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005437155,"about_ca_topic_score_gemma":0.0006087117,"domain_scores_codex":[0.9999083,0.00001148843,0.000007486434,0.00001874884,0.00002140131,0.00003240207],"domain_scores_gemma":[0.9999156,0.00001020123,0.0000311761,0.000005867958,0.000004610449,0.00003242642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001314429,0.00001676907,0.0000435611,0.00001328082,0.000002333888,0.00001457889,0.00000345022,0.00001804634,0.9995648,0.00002133715,0.00001096323,0.0001593238],"study_design_scores_gemma":[0.00006509994,0.0004497852,0.00561362,0.000004122255,0.00001843548,0.0002292467,0.00002316389,0.0006403524,0.9914448,0.00004059539,0.001466447,0.000004398155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983324,0.0003896007,0.0006762611,0.00005405811,0.0000142948,0.00001277016,0.0001762189,0.00002795702,0.000316502],"genre_scores_gemma":[0.9968414,0.0003756024,0.0009081685,0.00004602009,0.000007667369,0.00002192495,0.0004561298,0.00001783295,0.001325151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00213677,"threshold_uncertainty_score":0.007148206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02999960661119502,"score_gpt":0.2865222545493403,"score_spread":0.2565226479381453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}