{"id":"W2056234356","doi":"10.1073/pnas.081474898","title":"Skp2 is oncogenic and overexpressed in human cancers","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":505,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"SKP2; Cancer research; Malignant transformation; Biology; Carcinogenesis; Cancer; Ubiquitin ligase; Tumor progression; Cell growth; Immunohistochemistry; Epithelial dysplasia; Ubiquitin; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008355809,0.0003860737,0.0001950151,0.0005548383,0.0002270843,0.00034678,0.0001122379,0.0002552042,0.002177506],"category_scores_gemma":[0.0001241652,0.0001486249,0.0001615252,0.0005702687,0.0002180409,0.0001222125,0.0003723211,0.0002281758,0.0006478874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000307594,"about_ca_system_score_gemma":0.0002620022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009063627,"about_ca_topic_score_gemma":0.0007402037,"domain_scores_codex":[0.9998877,0.000007949436,0.00000899618,0.00002376858,0.00004522717,0.0000264607],"domain_scores_gemma":[0.9999301,0.000006309568,0.00001901282,0.000008441879,0.00001006558,0.00002597907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004582746,0.0000444035,0.01393386,0.0001803147,0.00004984446,0.003991514,0.00006144166,0.00015814,0.9696694,0.0005270831,0.001025891,0.009899898],"study_design_scores_gemma":[0.00007243995,0.0003844966,0.2049594,0.00003882126,0.0001809096,0.03632521,0.0001884432,0.002119341,0.6836471,0.0006198139,0.07143874,0.00002536197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819503,0.007639978,0.001873064,0.0002222439,0.0000668834,0.00003608976,0.00216743,0.0003283782,0.005715668],"genre_scores_gemma":[0.9933075,0.001831286,0.0005049275,0.00003658372,0.0000178235,0.00002424927,0.001462559,0.00001393066,0.002801031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177506,"threshold_uncertainty_score":0.007284462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04187465270683729,"score_gpt":0.3288935179701433,"score_spread":0.2870188652633061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}