{"id":"W2056342910","doi":"10.1038/gene.2010.47","title":"A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles","year":2010,"lang":"en","type":"article","venue":"Genes and Immunity","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; University of Calgary; Hôpital Fleurimont; Université de Montréal; Queen Elizabeth II Health Sciences Centre; Centre Hospitalier de l’Université de Montréal; Manitoba Health; Montreal General Hospital; Dalhousie University; Ottawa Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research; Arthritis Research Centre of Canada; St Joseph's Health Centre; Toronto Western Hospital; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Lupus Canada; University Health Network","keywords":"Biology; PTPN22; Immunology; IRF5; Single-nucleotide polymorphism; Genetics; Major histocompatibility complex; Allele; Genome-wide association study; Gene; Immune system; Genotype; Interferon regulatory factors; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000627209,0.0001290673,0.0001780872,0.00003610267,0.0001318288,0.00005452316,0.000129847,0.0001590459,0.00001214758],"category_scores_gemma":[0.0002971467,0.0001226487,0.00005528981,0.00008328994,0.00003155049,0.000007620739,0.0001315152,0.0001651581,0.000003517284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001726613,"about_ca_system_score_gemma":0.0000285671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007539248,"about_ca_topic_score_gemma":0.009179268,"domain_scores_codex":[0.9990592,0.0001543326,0.0002224304,0.0002322663,0.0001010702,0.000230708],"domain_scores_gemma":[0.9994442,0.00003472639,0.0001128373,0.0002830565,0.0000846585,0.00004053622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001756474,0.0001879126,0.6224124,0.00001349064,0.00004003205,4.065579e-7,0.0002331704,0.000004949683,0.3764332,0.000001975274,0.00009355081,0.0005613115],"study_design_scores_gemma":[0.002820917,0.0003000291,0.9512973,0.00001670775,0.00004022515,0.000007596502,0.01133831,0.0001498027,0.032308,0.00010928,0.001228602,0.0003832059],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978842,0.00134424,0.000006092851,0.00002715912,0.0003186323,0.0003103484,0.00002054947,0.00001428467,0.00007449049],"genre_scores_gemma":[0.9991805,0.0002577571,0.00002583976,0.00002051108,0.00003999595,0.00002861171,0.00008763266,0.00001178838,0.0003473692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3441252,"threshold_uncertainty_score":0.5122247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006368909858116077,"score_gpt":0.2272407111259487,"score_spread":0.2208718012678326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}