{"id":"W2056342910","doi":"10.1038/gene.2010.47","title":"A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles","year":2010,"lang":"en","type":"article","venue":"Genes and Immunity","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; University of Calgary; Hôpital Fleurimont; Université de Montréal; Queen Elizabeth II Health Sciences Centre; Centre Hospitalier de l’Université de Montréal; Manitoba Health; Montreal General Hospital; Dalhousie University; Ottawa Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research; Arthritis Research Centre of Canada; St Joseph's Health Centre; Toronto Western Hospital; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Lupus Canada; University Health Network","keywords":"Biology; PTPN22; Immunology; IRF5; Single-nucleotide polymorphism; Genetics; Major histocompatibility complex; Allele; Genome-wide association study; Gene; Immune system; Genotype; Interferon regulatory factors; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008455789,0.0007953311,0.000516272,0.001157988,0.0006346152,0.0005305925,0.0003656064,0.0007351863,0.002738024],"category_scores_gemma":[0.001814827,0.000314124,0.0006950029,0.0008801281,0.0004265847,0.0001604846,0.0005075824,0.0006756374,0.0002808304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722513,"about_ca_system_score_gemma":0.0002156416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123168,"about_ca_topic_score_gemma":0.001105747,"domain_scores_codex":[0.9990392,0.0003778103,0.00007367069,0.0003142601,0.0001073364,0.00008781596],"domain_scores_gemma":[0.9987655,0.0005550461,0.0002579728,0.0001114462,0.00007550905,0.0002345804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01333067,0.001037662,0.5266109,0.0001298354,0.001861366,0.009764725,0.0007161642,0.000504398,0.4232042,0.001199642,0.0005939124,0.0210465],"study_design_scores_gemma":[0.0006820531,0.00239882,0.9535648,0.00003435122,0.002009602,0.01525792,0.0002580514,0.002072749,0.02111251,0.0007856922,0.001787694,0.00003565689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975922,0.0002353217,0.001441385,0.000089065,0.00001740821,0.00001206998,0.0001045622,0.0000241673,0.0004838643],"genre_scores_gemma":[0.9986833,0.00006319625,0.0006994942,0.00006480638,0.00001503716,0.000009267574,0.00006035183,0.00001015782,0.0003945326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002738024,"threshold_uncertainty_score":0.009159625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006368909858116077,"score_gpt":0.2272407111259487,"score_spread":0.2208718012678326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}