{"id":"W2056377087","doi":"10.1016/j.bmcl.2010.08.020","title":"Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: The effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring α-glucosidase inhibitor","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo; Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Active site; Moiety; Stereochemistry; Sulfonium; Ether; Maltase; Glycosyl; Nucleophile; Enzyme; Organic chemistry; Catalysis; Salt (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070933,0.0002619135,0.0002420578,0.00006872033,0.0000902247,0.0002301854,0.0003061176,0.0003209622,0.0009619399],"category_scores_gemma":[0.0002387888,0.0001751143,0.0001472083,0.00008663784,0.0002872476,0.0002712495,0.0001060916,0.0005014951,0.0002219831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218717,"about_ca_system_score_gemma":0.0001823119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005255939,"about_ca_topic_score_gemma":0.000704638,"domain_scores_codex":[0.999899,0.00002455209,0.000008637593,0.00001683629,0.00002796614,0.00002303343],"domain_scores_gemma":[0.9999075,0.00004295424,0.0000186763,0.000008521798,0.000008058941,0.00001419599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005971022,0.00003120034,0.0001217024,0.00002185277,0.000004890469,0.00003269075,0.00001001762,0.0002689887,0.9978189,0.0000673039,0.00001436154,0.001010926],"study_design_scores_gemma":[0.00003707813,0.0003620005,0.0004557191,0.000001262627,0.00001072444,0.0001220652,0.000008231947,0.0007440826,0.9977815,0.000025616,0.0004478853,0.000003927892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985492,0.0003753198,0.0006972229,0.00004476583,0.000006068754,0.000007455183,0.00007287184,0.00001114745,0.0002360077],"genre_scores_gemma":[0.9982027,0.0003733899,0.0009209054,0.00002214452,0.00000470041,0.00000580854,0.0001390372,0.00001004806,0.0003212799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009619399,"threshold_uncertainty_score":0.003217995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007643123777622384,"score_gpt":0.2428488851384801,"score_spread":0.2352057613608577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}