{"id":"W2056421884","doi":"10.1038/sj.mp.4001992","title":"Molecular studies of major depressive disorder: the epigenetic perspective","year":2007,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":303,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institute for Health and Care Research","keywords":"Epigenetics; Major depressive disorder; DNA methylation; Histone; Epigenesis; Autism spectrum disorder; Psychology; Genetics; Computational biology; Cognition; Biology; Neuroscience; Bioinformatics; Psychiatry; DNA; Gene; Autism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000480296,0.0006979806,0.001180245,0.0001943386,0.0001672077,0.00002919264,0.0007766162,0.0005155131,0.000008346718],"category_scores_gemma":[0.0002496951,0.0005111481,0.001132281,0.0004400715,0.0003675167,0.000002570366,0.0003661132,0.0003973577,0.00001271471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005101907,"about_ca_system_score_gemma":0.0004365349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002893458,"about_ca_topic_score_gemma":0.00005456149,"domain_scores_codex":[0.996811,0.0004645534,0.0009025419,0.0009125209,0.0004263304,0.0004830798],"domain_scores_gemma":[0.9972559,0.00006658477,0.0007593055,0.001399233,0.0004098842,0.0001091369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001287434,0.0009797227,0.0003850196,0.01868196,0.0124566,0.0001261445,0.0004602045,0.0006443326,0.01672243,0.01979451,0.0009521968,0.9286681],"study_design_scores_gemma":[0.0008325301,0.000615643,0.00002640982,0.002630984,0.003145226,0.00003944698,0.0006816026,0.000003757741,0.01686172,0.005335237,0.9685365,0.001290945],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001706506,0.9879451,0.007188808,0.0001298448,0.0007666461,0.001134261,0.00005856671,0.00001475243,0.001055503],"genre_scores_gemma":[0.001990195,0.9957741,0.001268274,0.00011997,0.0002753012,0.0001476113,0.0001557923,0.0001543378,0.0001144089],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9675843,"threshold_uncertainty_score":0.999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642943829395051,"score_gpt":0.3668078259139355,"score_spread":0.340378387619985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}