{"id":"W2056428844","doi":"10.1371/journal.pone.0011161","title":"Blockade of TRPM7 Channel Activity and Cell Death by Inhibitors of 5-Lipoxygenase","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; School of Medicine, Vanderbilt University; Queen's University; National Institutes of Health; Vanderbilt University","keywords":"TRPM7; HEK 293 cells; Arachidonate 5-lipoxygenase; Zileuton; Intracellular; Chemistry; Cell culture; Ion channel; Cell biology; Lipoxygenase; Pharmacology; Biochemistry; Biology; Arachidonic acid; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200655,0.0001082391,0.0002377753,0.000065142,0.00004971783,0.000005652317,0.00007301269,0.0001007041,0.00007475448],"category_scores_gemma":[0.0001400193,0.0001076114,0.00003484856,0.0000866645,0.00007050511,0.0000701474,0.00002872005,0.0001747145,0.000003933495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007986514,"about_ca_system_score_gemma":0.00003271771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004854299,"about_ca_topic_score_gemma":0.00003194881,"domain_scores_codex":[0.9991232,0.00004007731,0.0002044337,0.0001840642,0.000232176,0.0002160763],"domain_scores_gemma":[0.9991888,0.00009334425,0.0001485464,0.0002339816,0.00006662409,0.0002687511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004130449,0.002549768,0.007933425,0.001958926,0.000006207835,0.000001038633,0.0002250381,2.921546e-7,0.9861785,0.000005292906,0.0002312887,0.0004972083],"study_design_scores_gemma":[0.0007116061,0.0002519514,0.006388083,0.00002996411,0.0001052944,3.720985e-7,0.00002479554,0.0004838352,0.9917684,0.0001106073,0.00002319646,0.0001019578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978738,0.0002734496,0.000002388299,0.000490693,0.0001412215,0.0002783752,0.0001073705,0.00002624321,0.0008064615],"genre_scores_gemma":[0.9993006,0.000007495327,0.0003380262,0.00007318691,0.0001451619,0.00001300944,0.000006583174,0.00001612097,0.0000998213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005589867,"threshold_uncertainty_score":0.4388265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02327365879735501,"score_gpt":0.2362814174779918,"score_spread":0.2130077586806367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}