{"id":"W2056472275","doi":"10.1016/j.bmcl.2008.05.073","title":"Novel benzimidazole derivatives as selective CB2 agonists","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Benzimidazole; Agonist; Affinities; Selectivity; Moiety; Partial agonist; Binding affinities; Stereochemistry; Receptor; Chemical synthesis; Cannabinoid receptor type 2; Pharmacology; Combinatorial chemistry; Cannabinoid receptor; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783759,0.0004445238,0.0004128302,0.0003242327,0.000383003,0.0003596221,0.000836633,0.0003681809,0.007141646],"category_scores_gemma":[0.0001509023,0.0001985135,0.0001944559,0.0003150222,0.0002515592,0.0003162273,0.0003016335,0.0008305704,0.001185923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007317833,"about_ca_system_score_gemma":0.0002894861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002546635,"about_ca_topic_score_gemma":0.008557113,"domain_scores_codex":[0.9998976,0.00001516199,0.000006420159,0.0000127686,0.00001922689,0.00004881441],"domain_scores_gemma":[0.9999669,0.000006300311,0.000006537132,0.000003741033,0.00000544222,0.00001104812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001862492,0.0004216194,0.000369476,0.000777996,0.00004785679,0.0009908543,0.0002832817,0.001374917,0.9103381,0.005121765,0.005766303,0.07264528],"study_design_scores_gemma":[0.001147446,0.006191575,0.005300223,0.0001144221,0.0002007238,0.002224113,0.0001533071,0.003901084,0.8610585,0.0008406441,0.1187526,0.0001153294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8838463,0.04247724,0.007357666,0.001650778,0.000649118,0.0003491654,0.001550052,0.0007600423,0.06135955],"genre_scores_gemma":[0.9659548,0.01358378,0.002567203,0.000353486,0.0001050831,0.00009017556,0.0008782988,0.00003839207,0.01642864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007141646,"threshold_uncertainty_score":0.02389121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851940056862209,"score_gpt":0.2695736697128926,"score_spread":0.2510542691442705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}