{"id":"W2056472275","doi":"10.1016/j.bmcl.2008.05.073","title":"Novel benzimidazole derivatives as selective CB2 agonists","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Benzimidazole; Agonist; Affinities; Selectivity; Moiety; Partial agonist; Binding affinities; Stereochemistry; Receptor; Chemical synthesis; Cannabinoid receptor type 2; Pharmacology; Combinatorial chemistry; Cannabinoid receptor; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001841957,0.000340917,0.0004735005,0.0000781372,0.0002752303,0.0000191295,0.0002587093,0.0001747847,0.001228196],"category_scores_gemma":[0.0003703519,0.0002971731,0.0001647167,0.0005537345,0.0006873829,0.00007554166,0.00009545414,0.0007005815,0.0001059693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003947236,"about_ca_system_score_gemma":0.0007285076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001620348,"about_ca_topic_score_gemma":0.000001951585,"domain_scores_codex":[0.9973847,0.00002127386,0.0003587255,0.0005941061,0.0009617722,0.0006794672],"domain_scores_gemma":[0.9986398,0.00002482276,0.0001136691,0.000453945,0.0002217714,0.0005459659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002129983,0.0001960346,0.001815642,0.0001536022,0.0001181534,0.0004825761,0.0006509229,5.344373e-7,0.9101948,0.000006207304,0.08584283,0.0003257447],"study_design_scores_gemma":[0.0024986,0.0001449359,0.03682517,0.0001226072,0.00008024619,0.004970298,0.0004971597,0.00001562972,0.9283136,0.000006228287,0.02619174,0.0003338527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9448133,0.0004759555,0.0002157852,0.04925342,0.0001125104,0.0002949521,0.0000128569,0.0001245431,0.004696702],"genre_scores_gemma":[0.9879664,0.00009523599,0.000194069,0.005467795,0.001043134,0.00004095309,0.0000675476,0.0000629124,0.005061911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05965109,"threshold_uncertainty_score":0.999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851940056862209,"score_gpt":0.2695736697128926,"score_spread":0.2510542691442705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}