{"id":"W2056490499","doi":"10.1038/sj.onc.1206071","title":"Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2","year":2003,"lang":"en","type":"article","venue":"Oncogene","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; BRCA2 Protein; Replication protein A; DNA replication; DNA repair; Homologous recombination; Transcription (linguistics); Molecular biology; DNA-binding protein; DNA; Transcription factor; Cell biology; Genetics; Cancer research; Mutation; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882961,0.0001017921,0.0001049902,0.00003602519,0.0000397793,0.00002083715,0.0000545879,0.0001115775,0.00001515898],"category_scores_gemma":[0.00005832515,0.0001132329,0.00002554532,0.00008453571,0.00001854411,0.000008024502,0.00002284199,0.00006050686,0.000002607266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005678683,"about_ca_system_score_gemma":0.0000465576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001250257,"about_ca_topic_score_gemma":0.00005207437,"domain_scores_codex":[0.9991464,0.00007226927,0.0001790766,0.0003899238,0.00008055172,0.0001317615],"domain_scores_gemma":[0.9995553,0.000005794377,0.0000981176,0.0002525535,0.00004042676,0.00004776808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003184972,0.00002796034,0.001595598,0.00001458508,0.0000164415,8.172204e-7,0.00008034152,0.000005229774,0.9828942,0.00002275861,0.0001871367,0.01512309],"study_design_scores_gemma":[0.0006799764,0.0001316814,0.0004824048,0.00003361397,0.00001254239,0.000007748897,0.00005072682,0.0001838062,0.9912579,0.0001899907,0.006846219,0.0001234114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959387,0.0004736752,0.002430854,0.0001600165,0.0000413429,0.0004283092,0.00002743008,0.00001385921,0.0004858289],"genre_scores_gemma":[0.9973716,0.00004386571,0.001807339,0.0001105654,0.00005224907,0.0001365971,0.0001473212,0.00001839335,0.0003120328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01499968,"threshold_uncertainty_score":0.4617505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365938041041602,"score_gpt":0.2878431931969178,"score_spread":0.2741838127865018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}