{"id":"W2056536159","doi":"10.1016/j.canlet.2005.11.017","title":"The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action","year":2006,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Cyclin-dependent kinase 1; Cytotoxicity; Chemistry; Cell cycle checkpoint; Cell cycle; Apoptosis; Cell biology; Cancer research; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000311206,0.0004560489,0.0005106352,0.0005362434,0.0004398412,0.001006228,0.0003233831,0.0006991802,0.001511306],"category_scores_gemma":[0.0002280472,0.0001364107,0.0004936631,0.0002318035,0.0005390928,0.0005316506,0.0004008852,0.0007502564,0.0003673144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008702198,"about_ca_system_score_gemma":0.0003892528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007060421,"about_ca_topic_score_gemma":0.001077561,"domain_scores_codex":[0.9997743,0.00004193162,0.00001116914,0.00003621059,0.00008286332,0.00005356705],"domain_scores_gemma":[0.9998052,0.00004063789,0.00004147301,0.00003435165,0.00003721582,0.00004117137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007541935,0.00008920999,0.001640256,0.0002923189,0.00007182889,0.000601961,0.00007155718,0.0004386982,0.9531823,0.007288586,0.000460842,0.03510826],"study_design_scores_gemma":[0.00008099607,0.0008565515,0.007903767,0.00003405114,0.00007098268,0.00154303,0.0001104558,0.0009319457,0.9697143,0.002371297,0.01635884,0.00002365831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8537791,0.09074755,0.02157218,0.004125893,0.0003614374,0.0001476774,0.0003856886,0.000336115,0.02854443],"genre_scores_gemma":[0.9823217,0.009408459,0.002113187,0.0001877989,0.0000809082,0.00002200648,0.0001398482,0.000009142356,0.005716958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511306,"threshold_uncertainty_score":0.00631386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02405469861006131,"score_gpt":0.2528078555548161,"score_spread":0.2287531569447548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}